Gastrointestinal perforation is a common cause of acute abdomen due to peritonitis. The etiology and pathophysiology gastrointestinal perforations varied can range from small prepyloric that relatively clean transection or large bowel with spillage contents in peritoneum gross contamination. Some these are more than others. Here we present 6 cases rare presenting us the casualty, their manageme...

MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for degradation. The RING domain is essential for the E3 activity of MDM2, and we show here that the extreme C-terminal tail of MDM2 is also critical for efficient E3 activity. Loss of E3 function in MDM2 mutants deleted of the C-terminal tail correlated with a failure of these mutants to oligomerize with MDM2, o...

We read in earnest the retrospective study by Kerlin et al 1 in the recent issue of CHEST (April 2015), which found that nighttime intensivist staffi ng is not associated with a reduction in ICU or hospital mortality rate and overall length of stay. Th is study, as the authors noted, supports the existing body of work, from a single-center randomized controlled trial, multicentered observation...

OBJECTIVES to review the results of index operations in vascular surgery and to evaluate the impact of a specialist vascular training programme on patient outcome. METHODS we undertook a 5-year (January 1995-December 1999) review of the weekly-collected mortality and morbidity data. The total number, 30-day mortality and stroke rate of all index operations i.e. AAA repairs (ruptured and elect...

BACKGROUND Preconception care (PC) aims to identify and reduce a number of modifiable factors that can adversely affect pregnancy outcome. AIM To ascertain both knowledge of the attitudes towards PC among members of primary health care teams (PHCTs) and registered women of childbearing age in a representative sample of general practices in Harrow. METHOD A questionnaire survey was conducted...