Although many factors have been cited as the cause of acne, it has become apparent that hormonal inIfuences play a major role in its development. Hamilton (1) presented convincing evidence that testosterone propionate would produce acne in susceptible individuals and pointed out the absence of acne in eunuchs. It has been found, too, that the administration of ACTH and cortisone, both of which ...

A wide range of synthetic chemicals and their metabolites present in the environment can antagonise the receptor activity of androgen hormones present in wildlife and humans. With increasing global production of new synthetic chemicals, little is known about their environmental fate, health consequences and end-points. This study was conducted to identify and characterise chemicals with anti-an...

Development of an internationally recognized standard for the Hershberger assay as a screening tool to detect potential (anti-)androgenic chemicals is in progress. In the present preliminary study, we evaluated the reliability of the enhanced Hershberger assay to detect thyroid hormone modulating activity, while concentrating attention on possible confounding influence on evaluation of (anti-)a...

One problem in aquaculture is obtaining brood because many commercially important species are incapable of spontaneous maturation under artificial conditions. Commercial shrimp hatcheries commonly use eyestalk ablation to stimulate gonadal maturation in shrimps. Research has been conducted on the inhibition of reproductive maturation by hormones originating in the eyestalk glands and on other e...

The effect of glucocorticoid hormones on the replication of human cytomegalovirus (HCMV) was studied in human embryonic lung (HEL) cells. Treatment of cells with pharmacological concentrations of adrenal glucocorticoids such as dexamethasone enhanced HCMV replication; treatment with oestrogenic or androgenic hormones did not do so. In dexamethasone-treated HEL cells there was an approximately t...

Integrity of the portal vein is a condition for normal function of the reproductive tract in female rats. Section of the portal vein (PVS) always abolished periodic sexual function. In a series of 23 animals, 6 developed continuous estrus and other signs of the presence of excessive amounts of estrogenic hormones; yet the ovaries of these rats were small. In 6 other rats there was growth of the...

Serum levels of testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone sulfate, and sex hormone-binding globulin and urinary levels of testosterone and androstanediol were compared in 75 women with breast carcinoma and 150 age-matched healthy controls. Odds ratios for quartiles of hormones, adjusted for known potential confounders, were computed using conditional logistic re...

DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to activate the human AR, ER, and GR and determine the relative androgenicity, estrogenicity, and glucocorticoid activity. The results show that, a...

Involutional changes in the androgenic activity of the male body occur gradually and exhibit high intraand interpopulational differentiation. These differences make quantitative description of physiological ageing of the male endocrine system considerably difficult. There are also no commonly accepted normal levels for gonadotropin and sex hormone. In the present study the authors have made an ...