MicroRNAs (miRNAs) are known as a new class of small RNAs (18-25 nucleotides) that regulate gene expression at multiple levels from transcription to translation. Considering the important role of miRNAs in cell proliferation, differentiation, and apoptosis, any variations in their expression can contribute to various anomalies, such as tumorigenesis. Single-nucleotide polymorphisms (SNPs) have ...

Background:The incidence rate of head and neck cancer in the world is about 560,000 new cases a year. Larynx cancer is the most common malignancy in head and neck in Iran. The most common head and neck carcinoma is the malignancy of squamous epithelial cells. This study was conducted to determine the survival rate of patients undergoing nonsurgical treatment methods for larynge...

introduction: to evaluate the efficacy and safety of carboplatin plus paclitaxel in patients with advanced locoregional recurrence and metastatic endometrial cancer. patient and method: 32 eligible patients (median age 62, range 41-72) with measurable endometrial cancer were treated with carboplatin (auc= 6) and paclitaxel (175 mg/m 3 ) every 4 weeks for 6 cycles, or, until disease progression ...

Multiple Sclerosis (MS) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. In this study for evaluation effect of mercuric on progression of MS we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model of MS in C57BL/6 mi...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

Coronavirus pneumonia has been detected in Wuhan City since December 2019. Today, coronavirus 2019 (COVID-19) has become an epidemic worldwide. Although this disease is not fully understood, it can show different symptoms over time. One of the components involved in the body by this virus is platelets that communicate directly with several different types of viruses, including the SARS-CoV viru...

Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is ...

Objective(s) Matrix metalloproteinases comprise a family of enzyme that is able to degrade components of extra cellular matrix. There are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility. The aim of this study was to analyses association between MMP2 and MMP9 promoter polymorphisms and head and neck squamous cell carcinoma...

background: in 30 to 40% of patients with type 2 diabetes mellitus (t2dm) nephropathy is developed. the aim of the present study was to find the synergistic effect of two polymorphisms of methylenetetrahydrofolate reductase (mthfr) c677t and angiotensin converting enzyme insertion/ deletion (ace i/d) polymorphism on the risk of diabetic nephropathy and its progression. methods:   in a case-cont...