La sfida raccolta da DULP richiede un approccio innovativo che consenta di riconsiderare le pratiche e l'idea di formazione, allo scopo di offrire supporto a forme di apprendimento che vanno assumendo un carattere temporale, spaziale e culturale sempre più ubiquo e che si svolgono in contesti sempre più liquidi e coevolutivi, in cui l'individuo deve necessariamente apprendere a gestire la propr...

The paper compares conventional and final-offer arbitration from the welfare perspective. By some existing contractual arrangement, one party is supposed to make a payment to the other party, depending on the state of the world. Under asymmetric information, one party has a better signal about the state of the world and the other party is aware about its informational disadvantage. Then the ran...

There are several classes of interior point algorithms that solve linear programming problems in O(Vin L) iterations, but it is not known whether this bound is tight for any interior point algorithm. Among interior point algorithms, several potential reduction algorithms combine both theoretical (O(+/E L) iterations) and practical efficiency as they allow the flexibility of line searches in the...

pemphigus vulgaris is an autoimmune disease, in which the role of th17 cytokines needs to be further explored. this study was performed to assess serum levels of three interleukins (il) required for th17 differentiation (il-1β, il-6 and il-23) and two specific th17 cytokines (il-17 and il-22) in a group of patients with pemphigus vulgaris, at baseline, 3 weeks and 6 months after of treatment. c...

background in some autoimmune diseases such as rheumatoid arthritis (ra), interleukin-27 (il-27) and il-33 levels are increased. these observations suggest that il-27 and il-33 may have a role in the pathogenesis of polymyositis/dermatomyositis (pm/dm). conclusions these data indicate that il-27 might be selectively involved in the pathogenesis of dm and pm. however, il-33 does not appear to be...

objective(s):il-12 as an anti-tumor cytokine and il-33 a novel identified cytokine with both pro- or anti-tumor activities, play important roles in response against tumor cells. our aim was to evaluate the il-12 and il-33 levels and single nucleotide polymorphisms (snp) in their genes in patients with breast cancer. materials and methods:blood samples were collected from 100 patients with breas...

Shiga toxins (Stxs) are bacterial virulence factors produced by Shigella dysenteriae serotype 1 and Escherichia coli strains. Stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. Additionally, Stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. The inflammatory cyto...

Background: Astrocytes, which comprise ~90% of overall brain mass, are involved in brain immunity. These cells represent the non-professional class of CNS-resident APCs and may promote or inhibit CNS inflammation depending on the cytokines they secrete. IL-10 family of cytokines and their receptors, IL-20R1 and IL-20R2, may have a role in shifting astrocytes to a neuroprotective or neurodegener...

Background: Periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. Environmental and genetic factors as well as the immune system participate in this process. Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. Objective: To assess and compare the levels of IL-4, IL-6 and IL-...

Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...