We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes, one that creates tyrosine-RNA nucleopeptides and another that phosphorylates tyrosine side chains, we find substantial improvements in yield, kobs, and Km for peptide substrates due to recruiting by His6/Cu(2+). Howeve...

We present a molecular theory to study the adsorption of different species within pH-sensitive hydrogel nanofilms. The theoretical framework allows for a molecular-level description of all the components of the system, and it explicitly accounts for the acid-base equilibrium. We concentrate on the adsorption of hexahistidine, one of the most widely used tags in bio-related systems, particularly...

gilooyeh clan or rouzbeh family was one of the most famous and effective iranian clans of fars during the first three centuries sassanids who was gradually successful to penetrate in abbasid caliphate and to show their important roles in social- political events, in addition to their periodic battles with aggressive and dominant arabs. gilooyeh himself who was the most famous and prominent memb...

atrick Watson-Williams, though I know his son, and now his grandson is one of my ^leagues on the staff of the Manchester Royal Infirmary. Patrick Watson-Williams plonged to the golden age of British Otolaryngology; an age on the pages of whose ^story occur such names as Sir St. Clair Thomson, J. S. Fraser, Jenkins, Scott, Browne% and Paterson. They are now numbered amongst the immortals of our ...

more famous grandson Charles, but his practical inventions included a speakingmachine, horizontal windmills, and a new type of carriage. As one of the leading members of the celebrated Lunar Society of Birmingham, he became a close friend of Boulton, Watt and Wedgwood, while he became involved in a bitter controversy with another member, William Withering, over priority in the use of digitalis ...

The polar flagellum of Vibrio alginolyticus is rotated by the sodium motor. The stator unit of the sodium motor consists of four different proteins: PomA, PomB, MotX and MotY. MotX and MotY, which are unique components of the sodium motor, form the T-ring structure attached to the LP ring in the periplasmic space. MotY has a putative peptidoglycan-binding motif in its C-terminal region and MotX...