Pass, Jason M., Yuting Zheng, William B. Wead, Jun Zhang, Richard C. X. Li, Roberto Bolli, and Peipei Ping. PKCe activity induces dichotomous cardiac phenotypes and modulates PKCe-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol 280: H946–H955, 2001.—Receptors for activated C kinase (RACKs) have been shown to facilitate activation of protein kinase C (PKC). However, it is ...

In many data centers, server racks are highly underutilized. Rack slots are left empty to keep the sum of the server nameplate maximum power below the power provisioned to the rack, while the servers placed in the rack cannot make full use of available rack power. The root cause of this rack underutilization is that the server nameplate power is often much higher than can be reached in practice...

Rack-scale computers are dense clusters with hundreds of micro-servers per rack. Designed for data center workloads, they can have significant power, cost and performance benefits over current racks. The rack network can be distributed, with small packet switches embedded on each processor as part of a system-on-chip (SoC) design. Ingress/egress traffic is forwarded by SoCs that have direct upl...

The WD repeat-containing protein receptor for activated protein kinase C (RACK)-1 has been linked to a variety of signaling systems including protein kinase C, growth factors, and IFNs. In the IFN system, RACK-1 functions as an adaptor recruiting the transcription factor STAT1 to the receptor complex. However, RACK-1 should play a broader role in type I IFN signaling because mutation of the RAC...

Recent trends to pack data centers with more CPUs per rack have led to a scenario in which each individual rack may contain hundreds, or even thousands, of compute nodes using system-on-chip (SoC) architectures. At this increased scale, traditional rack-level star topologies with a top-ofrack (ToR) switch as the hub and servers as the leaves are no longer feasible in terms of monetary cost, phy...

Migrating cells and growth cones extend lamellipodial and filopodial protrusions that are required for outgrowth and guidance. The mechanisms of cytoskeletal regulation that underlie cell and growth cone migration are of much interest to developmental biologists. Previous studies have shown that the Arp2/3 complex and UNC-115/abLIM act redundantly to mediate growth cone lamellipodia and filopod...

Aging is associated with remodeling of the immune system, contributing to increased incidence of infections, autoimmune diseases, and cancer among the elderly. Alterations in several signal transduction pathways have been reported to play an important role in immunosenescence. We show that peripheral blood leukocytes obtained from old donors (> or =65 years) have a significantly reduced express...

The controlling behaviour of a vehicle is influenced by the performance of its steering system. The steering system consists of steering wheel, steering column, rack and pinion, steering gearbox, and a linkage system. The vehicle is controlled by the behaviour of the steering gear with the spring loaded rack and pinion. This spring loading arrangement consists of yoke nut, spring, and plunger. ...

Many data center traffic patterns exhibit abundant concurrent connections and high churn. In the face of these characteristics, server-centric congestion control is a poor fit—each connection, no matter how small, must start from scratch testing when and how much to send along a given path. This is despite the fact that there are a large number of flows that may have already probed the exact sa...

BACKGROUND Physical fitness tests are widely used to assess endurance, sprint ability, coordination and/or strength. The objective of the present study was to analyze the degree to which the results of the Bundeswehr Basis Fitness Test (BFT)--a physical fitness test comprising a sprint test (11 × 10-m shuttle test), a flexed-arm hang test and a 1000-m run--are consistent with the output measure...