For the first time, we have identified photospheric emission lines in the far-UV spectrum of a white dwarf. They were discovered in the Far Ultraviolet Spectroscopic Explorer spectrum of the hot (Teff ≈ 200 000 K) DO white dwarf KPD 0005+5106 and they stem from extremely highly ionized calcium (Ca X λλ 1137, 1159 Å). Their photospheric origin is confirmed by non-LTE line-formation calculations....

The use of mathematical models to study cardiac electrophysiology has a long history, and numerous cellular scale models are now available, covering a range of species and cell types. Their use to study emergent properties in tissue is also widespread, typically using the monodomain or bidomain equations coupled to one or more cell models. Despite the relative maturity of this field, little has...

Research in systems biology enhanced our knowledge of biological environments. Many discoveries are recorded in computational models which encode the structure of biological networks, and describe their temporal and spatial behavior. Due to tremendous efforts by the research community, the number of openly available models is numerous and still continually increasing [1]. To support the sharing...

The amount of information generated by research in biological science has lead to an intensive use of models. Mathematical and computational modeling need accurate description to share, reuse and simulate models as formulated by original authors. In this paper we introduce the Cell Component Ontology CelO, an ontology expressed in OWL-DL. This ontology captures both the structure of a cell mode...

MOTIVATION The creation and exchange of biologically relevant models is of great interest to many researchers. When multiple standards are in use, models are more readily used and re-used if there exist robust translators between the various accepted formats. SUMMARY Antimony 2.4 and JSim 2.10 provide translation capabilities from their own formats to SBML and CellML. All provided unique chal...

Are severe depressive symptoms prospectively associated with disability pension? To answer that question, we linked data from a representative sample of the Danish workforce with disability pension (DP) award data from the National Registry on Public Transfer Payments. Of the 5106 study participants, 111 employees (2.2%) received DP during the 10-year follow-up. Severe depressive symptoms, repo...

The amount of information generated by biological research has lead to an intensive use of models. Mathematical and computational modeling needs accurate description to share, reuse and simulate models as formulated by original authors. In this paper, we introduce the Cell Component Ontology CelO, expressed in OWL-DL. This ontology captures both the structure of a cell model and the properties ...

Summary The Simulation Experiment Description Markup Language (SED-ML) is a standardized format for exchanging simulation studies independently of software tools. We present the SED-ML Web Tools, an online application for creating, editing, simulating and validating SED-ML documents. The Web Tools implement all current SED-ML specifications and, thus, support complex modifications and co-simula...

Many researchers in the last couple of decades have suggested that glucose absorption small intestine depends on both constitutively expressed SGLT1 and translocated GLUT2 brush border membrane, especially presence a high concentration luminal glucose. Afshar et al. generated computational model non-isotonic uptake by intestinal epithelial cells. The incorporates apical via GLUT2, basolateral e...

We describe an implemented model of glucose absorption in the enterocyte, as previously published by Afshar et al. (2019), The used mechanistic descriptions all responsible transporters and was built CellML framework. It validated against experimental data a modular structure which allows each individual transporter to be edited independently from other transport protein models. composite then ...