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The carcinogenicity of N-( 5-Nitro-2-furfurylidene )-1-aminohydan to in (nitrofurantoin, NF-153) was examined in (C57BL/6N x DBA/2N)F1 (BDF1) mice. Three hundred of mice were divided into three groups, each group consisting about 50 male and 50 female mice. Nitrofurantoin was given in powdered diet at dose levels of 0. 3, 0. 075, or 0 % to the respestive group of mice. The overall incidence of ...
Non-human animals are frequently the research subjects in a variety of areas, particularly in the life sciences. In 1997, the Canadian Council of Animal Care reported that 1 474 611 non-human animals were tested as part of research, testing, and teaching in Canada, a reduction from the 2 075 923 non-human animals that were tested in 1985. Most of these were tested as part of basic research in t...
The nutritional factors which affect lead absorption have been studied. Synthetic diets of known composition were compounded to contain 0-075% Pb as PbCl2 labelled with 203Pb. Rats were exposed to lead for periods of 48 hr. The dietary intake was then measured and the absorption of lead determined by means of a whole-body counter. Lead absorption was increased by high fat, low mineral, low prot...
Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-fold allowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA)...
Modeling impacts of management alternatives on soil carbon storage of farmland in Northwest China F. Zhang, C. Li, Z. Wang, and H. Wu State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, CAS, Xi’an, 710 075, PR China Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, NH 03824, USA Graduate School, Chinese Academy of Science...
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