نتایج جستجو برای: anandamide

تعداد نتایج: 1669  

2002
Mauro Maccarrone Monica Bari Natalia Battista Alessandro Finazzi-Agrò

Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the mechanism for this benefit remains unclear. Here we show that at physiological concentrations estrogen activates the anandamide membrane transporter of human endothelial cells and leads to rapid elevation of calcium (apparent within 5 minutes) and release of nitric oxide ...

Journal: :Blood 2002
Mauro Maccarrone Monica Bari Natalia Battista Alessandro Finazzi-Agrò

Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the mechanism for this benefit remains unclear. Here we show that at physiological concentrations estrogen activates the anandamide membrane transporter of human endothelial cells and leads to rapid elevation of calcium (apparent within 5 minutes) and release of nitric oxide ...

2009
Jonathan Z. Long Weiwei Li Lamont Booker James J. Burston Steven G. Kinsey Joel E. Schlosburg Franciso J. Pavón Antonia M. Serrano Dana E. Selley Loren H. Parsons Aron H. Lichtman Benjamin F. Cravatt

2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). FAAH inhibitors produce a select subset of the behavioral effects ...

Journal: :Biological psychiatry 2016
Catherine H Demers Emily Drabant Conley Ryan Bogdan Ahmad R Hariri

BACKGROUND Preclinical models reveal that stress-induced amygdala activity and impairment in fear extinction reflect reductions in anandamide driven by corticotropin-releasing factor receptor type 1 (CRF1) potentiation of the anandamide catabolic enzyme fatty acid amide hydrolase. METHODS Here, we provide clinical translation for the importance of these molecular interactions using an imaging...

2018
Debra S. Karhson Karolina M. Krasinska Jamie Ahloy Dallaire Robin A. Libove Jennifer M. Phillips Allis S. Chien Joseph P. Garner Antonio Y. Hardan Karen J. Parker

Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent model...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Pál Pacher Sándor Bátkai Douglas Osei-Hyiaman László Offertáler Jie Liu Judy Harvey-White Attila Brassai Zoltán Járai Benjamin F Cravatt George Kunos

The endocannabinoid anandamide exerts neurobehavioral, cardiovascular, and immune-regulatory effects through cannabinoid receptors (CB). Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the in vivo degradation of anandamide. Recent experimental studies have suggested that targeting the endocannabinergic system by FAAH inhibitors is a promising novel approach for the treatment of a...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
C J Fowler G Tiger A Stenström

The ability of rat brain (minus cerebellum) homogenates to deamidate arachidonyl ethanolamide (anandamide) was determined with a custom-synthesized substrate, arachidonyl ethanolamide-[1-3H] ([3H]anandamide). Conditions whereby initial velocities were measured were established. The homogenates deamidated anandamide with a Km value of 0.8 microM and a Vmax value of 1.73 nmol . (mg protein)-1 . m...

Journal: :Pharmacological reports : PR 2014
Andrei Sibaev Birol Yuece Hans Dieter Allescher Dieter Saur Martin Storr Manfred Kurjak

BACKGROUND Endocannabinoids (EC) and the cannabinoid-1 (CB1) receptor are involved in the regulation of motility in the gastrointestinal (GI) tract. However, the underlying physiological mechanisms are not completely resolved. The purpose of this work was to study the physiological influence of the endocannabinoid anandamide, the putative endogenous CB1 active cannabinoid, and of the CB1 recept...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Jie Liu Lei Wang Judith Harvey-White Douglas Osei-Hyiaman Raj Razdan Qian Gong Andrew C Chan Zhifeng Zhou Bill X Huang Hee-Yong Kim George Kunos

The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released "on demand" by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis. Anandamide can be generated from its membrane precursor, N-arachidonoyl phosphat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
P C Schmid B C Paria R J Krebsbach H H Schmid S K Dey

Anandamide (N-arachidonoylethanolamine) is an endogenous ligand for both the brain-type (CB1-R) and spleen-type (CB2-R) cannabinoid receptors. This investigation demonstrates that the periimplantation mouse uterus contains the highest levels of anandamide (142-1345 pmol/micromol lipid P; 1-7 microg/g wet weight) yet discovered in a mammalian tissue. The levels fluctuate with the state of pregna...

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