The process of method validation has a direct impact on the quality of residue analytical data. Forensic laboratories are specifically in need of effective methods for the correct interpretation of toxicological findings. Unreliable data can lead to unjustified legal consequences or to wrong treatment of the patient. The importance of method validation is emphasized by Peters et al. [1] not onl...

A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Lichrosorb® (RP-18 column with a mobile phase consisting of acetonitrile – phosphate buffer (5:95v/v)) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical ...

O ermitão Clibanarius vittatus é um organismo típico de regiões intertidais estuarinas sendo considerado um possível bioindicador da presença de tributilestanho (TBT) nesses ambientes. Por esta razão, este estudo apresenta o desempenho analítico e a validação do método para quantificação de TBT em tecidos de C. vittatus por cromatografia gasosa com detector fotométrico de chama pulsante (GC-PFP...

Analytical methods development must be validated to provide reliable data for regulatory submissions. These methods are essential for a number of purposes, including testing for quality control release, testing of stability samples, testing of reference materials and to provide data to support specifications.Analytical method followed by process of establishing evidence that provides a high deg...

Immunoassays are now very widely used in the clinical laboratory, either because no other type of assay system is feasible or because they are often the most effective and suitable of the possible analytical methods. The last decade has seen the development and refinement of many new immunoassay reagents and systems. The major trend has been away from liquid-phase assays involving radioisotopic...

This paper deals with a three-dimensional numerical procedure based on the finite-element method for the modeling of finite-amplitude progressive acoustic waves. The method can predict the nonlinear propagation of acoustic fields produced by sources of arbitrary geometry. Based upon a perturbation method, a second-order analytical study is developed and the numerical procedure is formulated. Ba...