Climate factors influence the transmission of dengue fever, the world's most widespread vector-borne virus. We examined the potential added risk posed by global climate change on dengue transmission using computer-based simulation analysis to link temperature output from three climate general circulation models (GCMs) to a dengue vectorial capacity equation. Our outcome measure, epidemic potent...

To assess the status of global climate models (GCMs) in simulating upper-tropospheric ice water content (IWC), a new set of IWC measurements from the Earth Observing System’s Microwave Limb Sounder (MLS) are used. Comparisons are made with ECMWF analyses and simulations from several GCMs, including two with multi-scale-modeling framework. For January 2005 monthly and daily mean values, the spat...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

POLICY ACTION ON CLIMATE CHANGE IS INFORMED BY CLIMATE MODEL projections as described most recently in the Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC). The models used are general circulation models (GCMs), which numerically represent the physical climate system in three dimensions, including the hydrological cycle. These are complemented by recently de...

Climate simulations performed with general circulation models (GCMs) are widely viewed as the principal scientific basis for developing policies to address potential future global change scenarios (e.g. global warming, ozone depletion, changes in land use, etc.). Hence, there is a compelling need to systematically improve the performance of GCMs in simulating the present climate, and thereby to...

The detection and attribution of climate change in the observed record play a central role in synthesizing knowledge of the climate system. Unfortunately, the traditional method for detecting and attributing changes due to multiple forcings requires large numbers of general circulation model (GCM) simulations incorporating different initial conditions and forcing scenarios, and these have only ...

We present the Representative Temperature and Precipitation (T&P) GCM Subsetting Approach developed within the Agricultural Model Intercomparison and Improvement Project (AgMIP) to select a practical subset of global climate models (GCMs) for regional integrated assessment of climate impacts when resource limitations do not permit the full ensemble of GCMs to be evaluated given the need to also...

Homalium letestui Pellegr (Flacourtiaceae) is used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases and Yorubas of western Nigeria as an antidote. The hepatoprotective effect of the stem extract (200-600 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, tot...

Ranking the performance of global climate models (GCMs) is a notoriously difficult exercise. Multi-model comparison studies nearly always show that each model has strengths and weaknesses relative to others, and for many purposes the multi-model ensemble mean delivers better estimates than any individual model. Nevertheless, in regions like East Africa, where there is little consensus between m...

Global Circulation Models (GCMs) contributed to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) and are widely used in global change research. This paper assesses the performance of the AR4 GCMs in simulating precipitation and temperature in China from 1960 to 1999 by comparison with observed data, using system bias (B), root-mean-square error (RMSE), Pearson...