The present study establishes the analgesic and anti-pyretic activities of the ethanolic extract of leaves of Catharanthus roseus in the models used. Since antipyretic and analgesic activities are commonly mentioned as characteristic of drugs or compounds which have an inhibitory effect on prostaglandin biosynthesis, the yeast induced hyperthermia in rat model was, therefore, employed to invest...

In this study, the ethanol extract of Cissampelos pareira has been evaluated. The extract was tested for analgesic properties using both hot plate and acetic acid-induced writhing methods. Antiinflammatory effect was investigated using two different doses of 250 and 500 mg/kg body weight on Evans rats by carrageenan-induced paw edema test. The antipyretic activity was evaluated using Brewer's y...

Physalis minima Linn. (Family  Solanaceae) is commonly known as Ground Cherry or Sunberry. It is traditionally used as diuretic, purgative, analgesic, anthelmentic, febrifuge, vermifuge, abortificient, etc. Many steroidal lactones have been identified from the plant and it has been reported to possess antifertility, hypoglycemic, cytotoxic, antiulcer, antibacterial, anti-inflammatory, analgesi...

Acetaminophen (APAP) is an analgesic and antipyretic agent which may cause hepatotoxicity and nephrotoxicity with overdose in man and laboratory animals. In vivo studies suggest that in situ activation of APAP contributes to the development of nephrotoxicity. Associated with target organ toxicity is selective arylation of proteins, with a 58-kDa acetaminophen binding protein (58-ABP) being the ...

Aspirin (acetylsalicylic acid), with fewer adverse reactions than salicylic acid, was first generated as an antipyretic analgesic through acetylation of salicylic acid in the late 19th century [1-3]. Since then, aspirin has long been used as an ingredient in anti-inflammatory agents worldwide and is commonly used as a drug with antiinflammatory, antipyretic and analgesic effects, as well as ant...

The present study was aimed at evaluation of the anti-inflammatory, analgesic and antipyretic activities of petroleum ether and ethanolic extract of aerial parts of Mollugo pentaphylla Linn. In experimental standard models. The results showed that the ethanolic extract significantly reduce the edema induced by carrageenan within 1 to 3 hrs. post dosing and Cotton-pellet induced granuloma models...

The thiazolidin-4-one derivatives and the corresponding spiro compounds were synthesized from sulphanilamide and were evaluated for anti-inflammatory and analgesic activity in acute and sub acute models. Compounds were also evaluated for antipyretic and cyclooxygenase enzyme inhibitory activity. All the compounds showed significant antiinflammatory, analgesic and antipyretic activity at 100 mg/...

Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N-mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. The chemical structures were confirmed by means of their 1H-NMR, IR spectral data and elemental analysis. The compounds were screened for analg...

Wattakaka volubilis (Family: Asclepiadaceae) has been reported to possess medicinal effects. In the present study, the dried root ethanol extract of W. volubilis designated as 'the extract' was evaluated for pharmacological activity in rats and mice. The anti-inflammatory and antipyretic activities were evaluated in rodents. The analgesic activity was evaluated in mice models. In the acute toxi...