It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia, suggesting a similar role for these structures in placebo analgesia. Using positron emission tomography, we confirmed that both opioid and placebo analgesia are associated with...

Creating a just culture Key words: just culture, TeamSTEPPS, human error, briefing, huddle. Circulating while administering moderate sedation/analgesia Key words: moderate sedation/analgesia, RN circulator. Monitoring RN leaving room during administration of moderate sedation Key words: moderate sedation/analgesia, propofol. Screening for obstructive sleep apnea before administering moderate se...

Background: The regional anaesthesia has lot of benefits compared to general for lower abdominaland limb surgeries. Epidural is an ideal anesthetic technique abdominal and lowerlimb additives are used with Anesthetics Early onset action, To prolong the duration ofaction, Analgesia Improving quality block.Aims Objectives: aim this study was clinical efficacy Dexmedetomidine versus Fentanylas add...

women. The ideal labour analgesia technique should dramatically reduce the pain of labour, while allowing the parturient to actively participate in the birthing experience. In addition, it should have minimal effect on the fetus or the progress of labour. New labour analgesia techniques approach this goal. This lecture will review these new methods of pain relief for the parturient and will hig...

We have previously reported that stress analgesia sensitive to and insensitive to opiate antagonists can be differentially produced in rats by varying the severity or temporal pattern of inescapable footshock. In these studies, we give further evidence for the opioid and non-opioid bases of these paradigms of stress analgesia. We find that naloxone-sensitive analgesia demonstrates tolerance wit...

Editor’s points † Genetic polymorphism in the m-opioid receptor can affect systemic opioid analgesia. † The effects of the A118G polymorphism on analgesia and pruritus after intrathecal fentanyl for labour analgesia were compared in two ethnically distinct populations. † While there was no effect of the genetic polymorphism, there was a marked effect of the ethnically distinct groups on duratio...

Study Selection Studies were selected if they were randomised controlled trials (RCTs) that compared the outcome when analgesics were given before surgical incision with the outcome when the same medication was given after surgical incision. Studies that compared pre-emptive analgesia with no analgesia or that compared pre-emptive analgesia with pre-emptive analgesia plus analgesia given after ...

Study Selection Studies were selected if they were randomised controlled trials (RCTs) that compared the outcome when analgesics were given before surgical incision with the outcome when the same medication was given after surgical incision. Studies that compared pre-emptive analgesia with no analgesia or that compared pre-emptive analgesia with pre-emptive analgesia plus analgesia given after ...

BACKGROUND Thoracotomy induces severe postoperative pain and impairment of pulmonary function, and therefore regional analgesia has been intensively studied in this procedure. Thoracic epidural analgesia is commonly considered the "gold standard" in this setting; however, evaluation of the evidence is needed to assess the comparative benefits of alternative techniques, guide clinical practice a...