Alzheimer's disease (AD) and diabetes mellitus (DM) are related to abnormal changes in enzyme activity. While acetylcholinesterase (AChE) butyrylcholinesterase (BChE) the primary targets treatment of (AD), α-glucosidase (α-Gly) α-amylase (α-Amy) enzymes known for (DM). Here, benzenesulfonamide-based thiourea thiazolidinone derivatives such as AChE, BChE, α-Gly, α-Amy inhibitors were reported. T...

In the current investigation, 474 endophytic fungi were isolated from 1200 plant parts of four species Indian traditional medicinal Salacia collected in different seasons. Among them, Fusarium oxysporum, Penicillium notatum, Pestalotiopsis sps and Phoma as a dominant genus S. chinensis, oblonga, fruticosa macrosperma respectively. Most isolates have shown potential anti-diabetic activity throug...

We investigated the structural requirements for bombesin (BB)-like peptides to stimulate amylase secretion in rat pancreatic acini and examined the responsible intracellular signal transduction pathways. The tetradecapeptide BB-(1-14) was a full agonist, whereas the heptapeptide BB-(8-14) did not evoke amylase secretion. The mammalian BB analog neuromedin C decapeptide [NMC-(5-14)] was as poten...