Antimicrobial peptides (AMPs) have attracted attention as next-generation antimicrobial drugs. Designing AMPs while considering multiple properties, such activities and toxicity, requires numerous trials errors by chemists. In...

Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can induce chemokine production, accelerate angiogenesis, and wound healing and modulate apoptosis in multicellular organisms. Originally, their antimicrobial mechanism of action was thought to consist solely of an inc...

Despite their limitations, mental status tests and self/proxy reports of instrumental activities of daily living (IADL) are often used to predict functional competence. In contrast, the Assessment of Motor and Process Skills (AMPS) is a direct observational assessment of IADL competence. Sixty-four community-dwelling elderly (20 Alzheimer's disease [AD] patients and 44 nondemented) were assesse...

The overlay of an intelligent Frequency Diversity Spread Spectrum System (FDSS) on the Advanced Mobile Phone Service system (AMPS) is studied. The worst-case condition is considered for the downlink analysis. Moreover, the effect of sidelobes outside the FDSS principal spectrum is considered. The downlink and uplink capacity of both systems are given using a model of 25 cells. Results show that...

Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial activity. Because of the increased frequency of resistance to conventional antibiotics there is an interest in developing AMPs as an alternative antibacterial therapy. Several cationic peptides that are derivatives of AMP...

Cationic antimicrobial peptides (AMPs) became a promising alternative to the conventional cancer drugs. We investigated the effects of 5 AMPs (melittin, galanin-mastoparan, cecropins A, B and P1) on the viability of HT-29 and AR-42J carcinoma cells. The viability of the cells was evaluated and used to calculate the AMPs therapeutic index. Also, cellular apoptosis and necrosis were analyzed. Mel...

The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly established in the literature, and most research articles on this topic conclude by stating that AMPs represent promising therapeutic agents against bacterial and fungal pathogens. Indeed, early research in this field showed that AMPs were diverse in nature, had high activities with low minimal inhibitory concentra...

26 Host defense antimicrobial peptides (AMPs) are a promising source of antibiotics for the 27 treatment of multiple drug-resistant pathogens. Lipopolysaccharide (LPS), the major 28 component of the outer leaflet of the outer membrane of Gram-negative bacteria, functions as 29 a permeability barrier against a variety of molecules including antimicrobial peptides (AMPs). 30 Further, LPS or endot...

Polymeric synthetic mimics of antimicrobial peptides (SMAMPs) have recently demonstrated similar antimicrobial activity as natural antimicrobial peptides (AMPs) from innate immunity. This is surprising, since polymeric SMAMPs are heterogeneous in terms of chemical structure (random sequence) and conformation (random coil), in contrast to defined amino acid sequence and intrinsic secondary struc...

This study concerns an attempt to establish a new method for predicting antimicrobial peptides (AMPs) which are important to the immune system. Recently, researchers are interested in designing alternative drugs based on AMPs because they have found that a large number of bacterial strains have become resistant to available antibiotics. However, researchers have encountered obstacles in the AMP...