The neat and lyotropic liquid crystalline phase behavior of three nonionic diethanolamide amphiphiles with C18 hydrocarbon chains containing one, two or three unsaturated bonds has been examined. This has allowed the effect of degree of unsaturation on the phase behavior of diethanolamide amphiphiles to be investigated. Neat linoleoyl and linolenoyl diethanolamide undergo a transition from a gl...

The relationship between the form of cell adhesion, ligand presentation, and cell receptor function was characterized using model Langmuir-Blodgett supported films, containing lipid-conjugated peptide ligands, in which isolated variables of the ligand presentation were systematically altered. First, the conformation of an adhesive Arginine-Glycine-Aspartic acid (RGD) peptide was varied by synth...

Two-dimensional electrochemical measurements were carried out with line microelectrodes positioned in the plane of the air/water interface to characterize the lateral mobilities of several long alkyl chain ferrocene amphiphiles possessing headgroups of different polarity. In the liquid range of mean molecular areas (MMA) of 55-95 Å2/molecule, the diffusion constants increase linearly with MMA. ...

DNA nanotubes were created using molecular self-assembly of single-stranded DNA (ssDNA)-amphiphiles composed of a hydrophobic dialkyl tail and polycarbon spacer and a hydrophilic ssDNA headgroup. The nanotube structures were formed by bilayers of amphiphiles, with the hydrophobic components forming an inner layer that was shielded from the aqueous solvent by an outer layer of ssDNA. The nanotub...

Dynamic octopus amphiphiles contain one charged "head," here a guanidinium cation, together several hydrophobic "tails" (or "tentacles") that can be attached and exchanged in situ by reversible hydrazone formation. Quite surprisingly, their ability to activate DNA as transporters in lipid bilayer membranes was found to increase with the number of tails (up to four) as well as with their length ...

Amphiphiles obtained by microbial fermentation, known as biosurfactants or bioamphiphiles, are reviewed in terms of their solution experimental and theoretical self-assembly properties, interface properties interactions with macromolecules.

I.F. Uchegbu et al. (eds.), Fundamentals of Pharmaceutical Nanoscience, DOI 10.1007/978-1-4614-9164-4_2, © Springer Science+Business Media New York 2013 Abstract Low molecular weight amphiphile micelles are formed from the selfassembly of comparatively hydrophilic amphiphiles (molecular weight <1,500 Da). These structures may be spherical or present as nanofi bres in the case of peptide amphiph...

Carbohydrate-based amphiphiles: self-assembled nanostructures of defined size and shape for various biomedical applications.

One of the grand challenges amphiphilic self-assembly is design ordered structures whose morphology or shape can be explicitly and dynamically controlled by adjusting properties amphiphiles their surroundings. Such a capacity would enable researchers to create synthetic systems with functionality that meets exceeds biological cells, provide robust platform for broad range engineering applicatio...

block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. in this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. the factor fphil is defined as the ratio of the number of hydroph...