A simple and sensitive kinetic spectrophotometric method has been developed and validated for determination of amlodipine besylate (AML). The method was based on the condensation reaction of AML with 7-chloro-4-nitro-2,1,3-benzoxadiazole in an alkaline buffer (pH 8.6) producing a highly colored product. The color development was monitored spectrophometrically at the maximum absorption λmax 470 ...

Corresponding Authors: Miss Trupti B. Solanki PG (QA) Research Scholar Quality Assurance Department, Anand Pharmacy College, Near Town Hall, Anand388 000, Gujarat, India Email: [email protected] Abstract: Aim: To develop and validate two novel spectrophotometric methods for the simultaneous determination of ternary mixture of Olmesartan medoxomil, Amlodipine besylate and Hydrochlorothiazide...

A simple, specific and sensitive high-performance liquid chromatographic (HPLC) method for determination of S (-) Amlodipine Besylate (SAB) and its related substance i.e. R (+) Amlodipine Besylate (RAB) in tablet formulation was developed and validated. The isomer separation was carried out using simple isocratic reversed-phase HPLC method using a chiral column. Isocratic elution at a flow rate...

BACKGROUND Elevated systolic blood pressure is more difficult to control than elevated diastolic blood pressure. The objective of this prespecified analysis of the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY) was to compare the efficacy of olmesartan medoxomil (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochloroth...

BACKGROUND Combination therapy with antihypertensive agents utilises different mechanisms of action and may be responsible for a more effective decrease in blood pressure. OBJECTIVE To review the recently published trials on efficacy and safety of the combination therapy with olmesartan and amlodipine. RESULTS The double-blind American COACH (Combination of Olmesartan Medoxomil and Amlopdin...