نتایج جستجو برای: aminobutyric acid a
تعداد نتایج: 13644008 فیلتر نتایج به سال:
Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. Interneurons do not produce BDNF themselves, but BDNF enhances their differentiation. Therefore, the question arose whether hippocampal interneurons regulate their phenotype by regulating BDNF expression and release f...
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination with a comparative model of the alpha1beta2gamma2 GABA(A) receptor leads to an orientation of the pharmacophore mo...
The non-classical, but frequently reported behavior of GABA(A) receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity...
Background and objectivesAmino acid neurotransmitters are closely correlated to the neurological function of brain, imbalance amino can lead a variety diseases. Therefore, development simple method detect five (aspartate, glutamate, glycine, taurine, γ-aminobutyric) in brain is urgently needed.
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