In the title compound {systematic name: cis-bis-[4-amino-N-(pyrimidin-2-yl)benzene-sulfonamidato-κ(2)N,N']bis-(butyl-amine-κN)copper(II) penta-hydrate}, [Cu(C(10)H(9)N(4)O(2)S)(2)(C(4)H(11)N)(2)]·5H(2)O or [Cu(sdz)(2)(ba)(2)]·5H(2)O [ba is butyl-amine and sdz = sulfadiazine(1-)], the copper(II) cation is six-coordinated by four N atoms of two sulfadiazine ligands and two N atoms of butyl-amine ...

Transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds is undoubtedly a straightforward and environmentally friendly method for the synthesis of a wide range of optically active heterocyclic compounds, which are widespread and ubiquitous in naturally occurring and artificial bioactive molecules. Over the past decade, a number of transition metal (Ir, Rh, Ru, and Pd) cat...

Annotation efforts in biosciences have focused in past years mainly on the annotation of genomic sequences. Only very limited effort has been put into annotation schemes for pharmaceutical ligands. Here we propose annotation schemes for the ligands of four major target classes, enzymes, G protein-coupled receptors (GPCRs), nuclear receptors (NRs), and ligand-gated ion channels (LGICs), and outl...

In the centrosymmetric dinuclear compound, [Co(2)Cl(4)(C(4)H(8)N(4))(2)], the Co(II) atom is coordinated by N atoms from two 3,5-dimethyl-1,2,4-triazol-4-amine ligands and two Cl atoms in a distorted tetra-hedral geometry. A six-membered ring is formed by four N atoms from two ligands and the two Co(II) centers; the Co⋯Co distance is 3.756 (9) Å.

The title dinuclear cadmium complex, [Cd(2)(NO(3))(4)(C(28)H(32)N(6))], is located on an inversion center. The unique Cd(II) ion displays a 5 + 2 coordination. A distorted square-pyramidal geometry is formed by the dipicolyl-amine group of the ligand via the N atoms in a meridional fashion and two O atoms of the nitrate ligands with short Cd-O distances. The coordination is completed by two loo...

Tubulin vinca-domain ligands can inhibit microtubule polymerization, causing cell death in mitosis, and their potential against multiple cancer types has been demonstrated. However, due to drug resistance toxicities, development of novel is still needed. In this study, we determined the high-resolution crystal structures vinorelbine, YXD, Phomopsin A complex with tubulin at 2.5 Å. Additionally,...