Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With...

N-Acetylation of (2,3,4,6-tetra-O-acetyl-a-D-glucopyranosyl) (2,3,4,6-tetra-0-acetyl-/?-D-glucopyranosyl)amine or bis(2,3,4,6-tetra-0-acetyl-/3-D-glucopyranosyl)amine afforded N-acetyl-bis(2,3, 4,6-tetra-0-acetyl-/3-D-glucopyranosyl)amine; deacetylation of the latter gave Af-acetyl-di-/3-Dglucopyranosylamine. Similarly, TV-acetylation of bis(2,3,4-tri-0-acetyl-/3-L-rhamnopyranosyl)amine led to ...

Spergualin (SG) and 15-deoxyspergualin (DSG) are derivatives of spermidine. Their substrate and inhibitor activities toward amine oxidase from bovine plasma were determined. SG was a good substrate of amine oxidase next to spermidine. The Km and Vmax for SG were 46.5 microM and 0.429 microM/minute, respectively, whereas the Km and Vmax for spermidine were 111 microM and 3.75 microM/minute, resp...

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.

It has been suggested that fluorescence from amine-containing dendrimer compounds could be the result of a charge transfer between amine groups and molecular oxygen [Chu, C.-C.; Imae, T. Macromol. Rapid Commun. 2009, 30, 89.]. In this paper we employ equation-of-motion coupled cluster computational methods to study the electronic structure of an ammonia-oxygen model complex to examine this poss...

1-(2,4-Dichlorophenyl)-3-(4-fluorophenyl)propen-1-one (1) was prepared and reacted with an active methylene compound (ethyl cyanoacetate) in the presence of ammonium acetate to give the corresponding cyanopyridone 2. Compound 2 reacted with hydrazine hydrate, malononitrile, ethyl bromoacetate and phosphorous oxychloride to afford compounds 4 and 7-11, respectively. The 2-chloropyridine derivati...

The synthesis and the evaluation as organocatalysts of new chiral guanidines derived from benzimidazoles in the enantioselective α-amination of 1,3-dicarbonyl compounds using di-t-butylazodicarboxylate as aminating agent is herein disclosed. The catalysts are readily synthesized through the reaction of 2-chlorobezimidazole and a chiral amine in moderate-to-good yields. Among all of them, those ...

Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme that catalyzes the oxidative deamination of endogenous and exogenous primary amines. SSAO exists in mammals both as a plasma-soluble and as a membrane-bound form, and its active site is able to come into contact with numerous xenobiotic, amine-containing compounds. The kinetic studies performed in this work showed that c...

Alkyl betaines and alkyl dimethylamine oxides have been shown to have pronounced antimicrobial activity when used individually or in combination. Although several studies have been conducted with these compounds in combinations, only equimolar concentrations of the C(12)/C(12) and C(16)/C(14) chain lengths for the betaine and the amine oxide, respectively, have been investigated. This study inv...