Taxol is a very important anticancer drug which was first isolated from Yew plant (Taxus spp.). However, Taxol supply by extraction from natural sources, has several limitations, and cannot meet current market's demands. Therefore, it seems necessary to use alternative production methods. Producing Taxol through biotechnological approaches is among the main options which have some advantages su...

Cellular manufacturing (CM) is one of the most important subfields in the design of manufacturing systems and as a recently emerged field of study and practice, virtual cellular manufacturing (VCM) inherits the importance from CM. One type of VCM problems is VCM with alternative processing routes from which the route for processing each part should be selected. In this research, a bi-objective ...

In last decade, the uncontrolled use of antibiotics as growth promoter for livestock has led to the appearance of antibiotic-resistant pathogens and increased risk of infectious diseases. This situation has triggered intensive research efforts to find safe alternative strategies. Certainly, the plants and vegetables and their derivatives as natural safe substances could be good candidates in th...

recovery of metabolites from fermentation broth by solvent extraction can be used to optimize fermentation processes. end-product reutilization, low product concentration, large volumes of fermentation broth and the requirements for large bioreactors, in addition to the high cost largely contributed to the decline in fermentative 2, 3-butanediol production. extraction can successfully be used f...