Autoimmune lymphoproliferative syndrome (ALPS) is an uncommon nonmalignant lymphoproliferative disease which is characterized by chronic, persistent or recurrent lymphadenopathy, splenomegaly, hepatomegaly, immune cytopenia , hypergammaglobinemia and increased risk of lymphoma. We report a 2-year old boy with hepatosplenomegaly as first presentation. Petechial and purpuric rashes with massive c...

The denudation budget of the Alps is quantified for the main period of lateral extrusion between 22 and 12 Ma. The relative importance of tectonic denudation increases from W to E from ,70% in the Lepontine window in the Swiss Alps to ,80% in the Tauern window and to more than 95% in the Rechnitz window. The driving mechanism of tectonic denudation was eastward extrusion due to an unconstrained...

ALPS is a framework for implementing and parallelizing tree search algorithms. It employs a number of features to improve scalability and is designed specifically to support the implementation of data intensive algorithms, in which large amounts of knowledge are generated and must be maintained and shared during the search. Implementing such algorithms in a scalable manner is challenging both b...

We present results from ambient noise tomography applied to temporary seismological stations in the easternmost part of the Alps and their transition to the adjacent tectonic provinces (Vienna Basin, Bohemian Massif, Southern Alps, Dinarides). By turning each station into a virtual source, we recover surface waves in the frequency range between 0.1 and 0.6 Hz, which are sensitive to depths of a...

Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in an accumulation of lymphocytes and childhood onset chronic lymphadenopathy, splenomegaly, multilineage cytopenias, and an increased risk of B-cell ly...

The European Alps are a mountain belt that is characterized by a series of discrete orogenic events, which have long been recognized. Despite the inherent episodic nature of orogenic evolution, the Alps have been continuously exhumed, mainly by erosion, but also by normal faulting. Since continental collision started in the late Eocene/Early Oligocene evidence for ongoing erosional exhumation h...

To reduce the problem of premature convergence we define a new attribute of an individual, its age, and propose the Age-Layered Population Structure (ALPS), in which age is used to restrict competition and breeding between members of the population. ALPS differs from a typical EA by segregating individuals into different age-layers by their “age” – a measure of how long the genetic material has...

The ALPS (Advanced Locking Plate System) fracture fixation system is a novel internal fracture fixation device designed and produced by Kyon Veterinary Surgical Products of Switzerland. Compared to conventional internal fixation systems the ALPS system is designed to reduce the rate of surgical infection, improve the rate of fracture healing, and improve surgical application versatility. All AL...