With less than 1% of patients who use benzodiazepines being affected, paradoxical responses to benzodiazepines are rare. In this case report, we outline the course of an 80-year-old female who developed a paradoxical response to benzodiazepines. Significant medical and psychiatric history includes anxiety, mood disorder, hypothyroidism, bilateral mastectomy, goiter removal, and triple bypass. T...

Introduction: Allium cepa is a biological material of great importance for mutagenicity tests, due to the simplicity of its use in testing, the fast growth of its roots, and the response of genetic material to the presence of substances with cytotoxic and genotoxic potential. Method: The Allium test model by using the onion seed (Alium cepa L.) without the use of pesticides or any other chemica...

BACKGROUND Triazolam has similar pharmacological properties as other benzodiazepines and is generally used as a sedative to treat insomnia. Alprazolam represents a possible alternative to midazolam for the premedication of surgical patients. The purpose of this study was to evaluate the anxiolytic, sedative, and amnestic properties of triazolam and alprazolam as pre-anesthetic medications. ME...

Alprazolam is effective as an anxiolytic and in the adjunct treatment of depression. In this study, the effects of calcium channel antagonists on the antidepressant action of alprazolam and imipramine were investigated. A forced swimming maze was used to study behavioral despair in albino mice. Mice were divided into nine groups (n = 7 per group). One group received a single dose of 1% Tween 80...

Benzodiazepines belongs to one of the most commonly used anxiolytic and anticonvulsant drugs in the world. Full description of toxic effects on different organs is lacking for nearly all the current benzodiazepines. The aim of the current work was to study the immunologic and vascular changes induced by sub-chronic administration of alprazolam and clonazepam in non-stressed and stressed adult m...

The effects of some psychotropic agents were evaluated on cognitive function in rats. Acute administration of antipsychotic agents chlorpromazine, haloperidol or pimozide-all inhibited the active avoidance response as elicited by pole climbing test-the least effect being seen with pimozide. The antianxiety benzodiazepines, lorazepam and alprazolam, also attenuated active avoidance learning with...

 Abstract Background: Postendodontic pain (PEP) has always been a major problem for patients and dentists and NSAIDs are being used to relieve PEP and it is supposed that some benzodiazepines may potentiate facilitate the analgesic effects of the NSAIDs. This study was conducted to evaluate the effect of alprazolam on the analgesic effect of ibuprofen in PEP treatment. Methods: This randomi...