نتایج جستجو برای: alpha tocotrienol

تعداد نتایج: 202822  

Journal: :Biochimica et biophysica acta 1991
J Phoenix R H Edwards M J Jackson

Previous studies have demonstrated that supplemental alpha-tocopherol inhibited calcium-induced cytosolic enzyme efflux from normal rat skeletal muscles incubated in vitro and suggested that the protective action was mediated by the phytyl chain of alpha-tocopherol [1]. In order to investigate this further a number of hydrocarbon chain analogues of tocopherol (7,8-dimethyl tocol, 5,7-dimethyl t...

2018
Nur-Vaizura Mohamad Soelaiman Ima-Nirwana Kok-Yong Chin

Background Patients receiving androgen deprivation therapy experience secondary hypogonadism, associated bone loss, and increased fracture risk. It has been shown that tocotrienol from Bixa orellana (annatto) prevents skeletal microstructural changes in rats experiencing primary hypogonadism. However, its potential in preventing bone loss due to androgen deprivation therapy has not been tested....

2010
Suzana Makpol Azrina Zainal Abidin Khalilah Sairin Musalmah Mazlan Gapor Md Top Wan Zurinah Wan Ngah

The effects of palm gamma-tocotrienol (GGT) on oxidative stress-induced cellular ageing was investigated in normal human skin fibroblast cell lines derived from different age groups; young (21-year-old, YF), middle (40-year-old, MF) and old (68-year-old, OF). Fibroblast cells were treated with gamma-tocotrienol for 24 hours before or after incubation with IC50 dose of H2O2 for 2 hours. Changes ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Kanjoormana A Manu Muthu K Shanmugam Lalitha Ramachandran Feng Li Chee Wai Fong Alan Prem Kumar Patrick Tan Gautam Sethi

PURPOSE Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective. Hence, novel agents that are safe and effective are urgently needed. Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in vitro and in a xenograft mouse model was investigated. EXPERIMENTAL DESIGN The effect of γ...

Journal: :Carcinogenesis 2013
Kazim Husain Barbara A Centeno Dung-Tsa Chen William J Fulp Marta Perez Guo Zhang Lee Noreen Luetteke Sunil R Hingorani Said M Sebti Mokenge P Malafa

The highly lethal nature of pancreatic cancer and the increasing recognition of high-risk individuals have made research into chemoprevention a high priority. Here, we tested the chemopreventive activity of δ-tocotrienol, a bioactive vitamin E derivative extracted from palm fruit, in the LSL-Kras(G12D/+);Pdx-1-Cre pancreatic cancer mouse model. At 10 weeks of age, mice (n = 92) were randomly al...

2012
Kanjoormana A. Manu Muthu K. Shanmugam Lalitha Ramachandran Feng Li Chee Wai Fong Alan Prem Kumar Patrick Tan Gautam Sethi

Purpose: Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatmentmodalities for gastric cancer are ineffective. Hence, novel agents that are safe and effective are urgently needed. Whether g-tocotrienol can sensitize gastric cancer to capecitabine in vitro and in a xenograft mouse model was investigated. Experimental Design: The effect of g-...

2016
Asaf A Qureshi Dilshad A Khan Neerupma Silswal Shahid Saleem Nilofer Qureshi

BACKGROUND Tocotrienols has been known to lower serum lipid parameters below 500 mg/d, while increase lipid parameters at higher dose of 750 mg/d. δ-Tocotrienol has a novel inflammatory property of concentration-dependent inhibition and activation. Therefore, inhibition (anti-inflammatory) property of tocotrienols at low doses is useful for cardiovascular disease, whereas, activation (pro-infla...

2015
Hui-Ling Che Doryn Meam-Yee Tan Puvaneswari Meganathan Yee-Lin Gan Ghazali Abdul Razak Ju-Yen Fu

Quantification of tocotrienols in human plasma is critical when the attention towards tocotrienols on its distinctive properties is arising. We aim to develop a simple and practical normal-phase high performance liquid chromatography method to quantify the amount of four tocotrienol homologues in human plasma. Using both the external and internal standards, tocotrienol homologues were quantifie...

Journal: :Anticancer research 2014
Suryatheja Ananthula Parash Parajuli Fathy A Behery Alaadin Y Alayoubi Khalid A El Sayed Sami Nazzal Paul W Sylvester

BACKGROUND Oxazine derivatives of tocotrienols display enhanced anticancer activity. Studies were conducted to further characterize these effects in vivo. MATERIALS AND METHODS Tetrazolium assay was used to determine the inhibitory effects of oxazine derivatives of γ-tocotrienol and δ-tocotrienol in vitro. These compounds were further formulated as lipid nanoemulsions and intralesional admini...

2014
Su-Wen Lim Hwei-San Loh Kang-Nee Ting Tracey D Bradshaw Nazariah A Zeenathul

BACKGROUND Tocotrienols, especially the gamma isomer was discovered to possess cytotoxic effects associated with the induction of apoptosis in numerous cancers. Individual tocotrienol isomers are believed to induce dissimilar apoptotic mechanisms in different cancer types. This study was aimed to compare the cytotoxic potency of alpha-, gamma- and delta-tocotrienols, and to explore their result...

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