The microtubule (MT) cytoskeleton gives cells their shape, organizes the cellular interior, and segregates chromosomes. These functions rely on the precise arrangement of MTs, which is achieved by the coordinated action ofMT-associated proteins (MAPs). We highlight the first andmost important examples of how different MAP activities are combined in vitro to create an ensemble function that exce...

Multidimensional nuclear magnetic resonance (NMR) provides one of the foremost analytical tools available to elucidate the structure and dynamics of complex molecules in their native states. Executing this kind of experiment generally requires collecting an n-dimensional time-domain signal S, from which the spectrum arises via an appropriate Fourier analysis of its various time variables. This ...

The Lie derivation of multivector fields along multivector fields has been introduced by Schouten (see cite{Sc, S}), and studdied for example in cite{M} and cite{I}. In the present paper we define the Lie derivation of differential forms along multivector fields, and we extend this concept to covariant derivation on tangent bundles and vector bundles, and find natural relations between them and...

This study was undertaken to localize the enzyme cyclic 3’,5’-adenosine monophosphatase in unstimulated human small lymphocytes. Cyclic AMP may be of importance in mediating lymphocyte stimulation, hence localization of the enzyme that is thought to modulate its intracellular concentration, cyclic AMPase, may point to the site of action of cyclic AMP in the cell. The histochemical technique

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We describe a system of stochastic differential equations (SDEs) which model the interaction between processive molecular motors, such as kinesin and dynein, and the biomolecular cargo they tow as part of microtubule-based intracellular transport. We show that the classical experimental environment fits within a parameter regime which is qualitatively distinct from conditions one expects to fin...

The mechanisms underlying two types of microtubule-dependent nuclear positioning are discussed. 'MTOC-dependent nuclear positioning' occurs when a nucleus is tightly associated with a microtubule organizing center (MTOC). 'Nuclear tracking along microtubules' is analogous to the motor-driven motility of other organelles and occurs when the nucleus lacks an associated MTOC. These two basic types...

In fungi, nuclear pore complexes are free to move through the nuclear envelope; however, little is known about how movement is regulated. New evidence reveals roles for molecular motors and potential impacts on genomic organization.

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