over a period of 48 years . ? . the biggest achievement which any single author could produce in his lifetime. A new and a very interesting chapter has rightly been devoted to ' Alloxan' diabetes, which can be produced in experimental animals by the injection of a chemical ' Alloxan' with almost unbelievable specificity. Alloxan is the ureide of mesoxalic acid and can be produced by oxidation o...

In most nations, diabetes mellitus is a serious and rising health issue. The goal of the study was to compare antidiabetic effects leaves extracts Decalepis hamiltonii in normal diabetic rats induced with alloxan. Using 120 mg/kg alloxan monohydrate, induced. order considerably lower blood glucose levels both alloxan-induced rats, D. methanolic extract given at doses 200 mg 400 mg, along gliben...

PURPOSE To determine the number of podocyte, slit diaphragms, slit diaphragm extensions and GBM thickness in diabetic nephropathy. METHODS Sixty "Rattus Wistar"of both sexes weighing 200-300 g were divided in two experimental groups: normal group 10 animals, and alloxan diabetic rats--50 animals. Alloxan was administered in a single IV dose of 42 mg/kg body weight. Body weight, water and food...

Chemiluminescence of luminol in a cell-free system was used to investigate the mechanism of alloxan-dependent free-radical generation. In the presence of alloxan and reduced glutathione (GSH), luminescence was greatly stimulated by FeSO4. Replacing GSH by oxidized glutathione or NAD(P)(H), or replacing FeSO4 by CUS04, ZnSO4 or FeCl3, did not yield chemiluminescence. The chemiluminescence of a m...

Background: Catalase deficiency (acatalasemia) is sensitive to alloxan, and the administration to acatalasemic mice develops hyperglycemia under mild conditions. However, the mechanism is still poorly understood. Methods: Alloxan was used to induce the oxidative stress and intraperitoneally administered to acatalasemic and normal mice. The blood samples of these mice after 1, 3, 5 and 7 days we...

Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan βcytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants leaves ...

The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the resistance to exogenous peroxide were approximately 20 times higher in liver and kidney than in is...

Our study aimed to assess the activity of blood antioxidant system in animal model alloxan-induced diabetes rats.Diabetes rats was induced by a single intraperitoneally injection freshly prepared 12% aqueous alloxan solution ( 200 mg/kg). The glucose level measured after 1, 2, 3, 10, 15, and 30 days from administration. included only those with levels above 250 mg/dl on 2nd day administration.W...

BACKGROUND Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as an oral antidiabetic agent in China for decades. However, the hypoglycemic activity of it has not yet been understood in terms of modern phar...

Alloxan is a polyoxy-pyrimidine of unusual biological interest, being the agent of choice for producing experimental diabetes (Shaw-Dunn, Sheehan, and McLetchie, 1943). Despite the fact that it has been used extensively for many years, very little is known of its ultimate fate in mammals or other forms of life. It is exceedingly unstable at physiological pH values and is spontaneously converted...