Sixty-one sets of clearance (CL) values in animal species were allometrically scaled for predicting human clearance. Unbound fractions (f(u)) of drug in plasma in rats and humans were obtained from the literature. A model was developed to predict human CL: CL=33.35 ml/min x (a/Rf(u))(0.770), where Rf(u) is the f(u) ratio between rats and humans and a is the coefficient obtained from allometric ...

Carbon accounting is at the heart of efforts to mitigate the effects of climate change. One approach for estimating population parameters for live tree stem carbon entails three primary steps: (1) construction of an individual tree, allometric carbon model, (2) application of the model to tree-level data for a probability sample of plots, and (3) use of a probability-based (design-based) estima...

Allometric and optimal hypotheses have been widely used to explain biomass partitioning in response to resource changes for individual plants; however, little evidence has been reported from measurements at the community level across a broad geographic scale. This study assessed the nitrogen (N) effect on community-level root to shoot (R/S) ratios and biomass partitioning functions by synthesiz...

Biomass is a promising renewable energy option that provides a more environmentally sustainable alternative to fossil resources by reducing the net flux of greenhouse gasses to the atmosphere. Yet, allometric models that allow the prediction of aboveground biomass (AGB), biomass carbon (C) stock non-destructively have not yet been developed for tropical perennial C4 grasses currently under cons...

OBJECTIVE Resting metabolic rate (RMR) is known to be proportional to body weight and to follow allometric scaling principles. We hypothesized that RMR can be predicted from an allometric formula with weight alone as an independent variable. RESEARCH METHODS AND PROCEDURES An allometric, power-law scaling model was fit to RMR measurements obtained from a cohort of patients being treated for w...

Recently, West et al. claimed to derive a general quantitative model based on fundamental principles for the allocation of metabolic energy between maintenance of existing tissue and the production of new biomass, and in addition claimed to derive a single, parameterless universal curve that describes the growth of many species. They further claimed that their model of the 3/4 exponent for the ...

Here, we advance novel uses of allometric spaces--multidimensional spaces specifically defined by allometric coefficients--with the goal of investigating the focal role of development in shaping the evolution of morphological disparity. From their examination, operational measures of allometric disparity can be derived, complementing standard signals of morphological disparity through an intuit...

The acyl composition of phospholipids from pectoral muscle of eight species of birds, ranging in size from the 13 g zebra finch to the 34 kg emu, were measured and combined with recent published results for a 3 g hummingbird. This represents an approximately 11000-fold range in body mass. Muscle phospholipids, and thus muscle membrane bilayers, from birds had a relatively constant unsaturated a...