نتایج جستجو برای: allelic frequencies

تعداد نتایج: 109218  

Journal: :Pharmacological reports : PR 2010
Negar Azarpira Soha Namazi Fatemeh Hendijani Maryam Banan Masumeh Darai

Research has shown that there are significant ethnic variations in the frequency of highly functional mutations in genes coding for metabolic enzymes. However, few studies have examined the frequency distribution of major allelic variations within the population of Iran. The present study focused on the genotype profile of southern Iranians in order to compare the allelic frequencies of CYP2C9,...

2005
An-Ning Feng Wei-Hsian Yin Mason Shing Young Ming-Wei Lin

Background: Human essential hypertension has a genetic basis, and hypertension is associated with altered endothelial nitric oxide (NO) release. We hypothesized that functional alterations of the endothelium-derived NO pathway in the presence of the 894G>T polymorphism of the endothelial NO synthase (eNOS) gene may be related to circadian variation of blood pressure in patients with essential h...

Journal: :thrita 0
siamak mirab samiee food and drug laboratory research center, ministry of health and medical education, tehran, ir iran; day general hospital laboratory, tehran, ir iran samira mohammadi yeganeh department of biotechnology, shahid beheshti university of medical sciences, tehran, ir iran mahdi paryan department of research and development, production and research complex, pasteur institute, tehran, ir iran houri rezvan day general hospital laboratory, tehran, ir iran ehsan mostafavi department of epidemiology, pasteur institute of iran, tehran, ir iran parvin pasalar department of clinical biochemistry, faculty of medicine, tehran university of medical sciences, tehran, ir iran; department of clinical biochemistry, faculty of medicine, tehran university of medical sciences, enghelab ave., tehran, ir iran. tel: +98-9121776031, fax: +98-2188795813

conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...

2017
Yaron Dekel Yossy Machluf Aviad Stoler Arava Aderet Daniel Baumel Efrat Kellerman Yoram Plotsky Oshrat Noked Partouche Gal Elhalal Izhar Ben-Shlomo Dani Bercovich

BACKGROUND Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and continents examined the allelic frequencies of the nt230(del4) MDR1 mutation, emphasizing the clinical im...

Journal: :Genetics 1990
A Gimelfarb

In a recent paper by GILLESPIE and TURELLI (1 989), the authors suggest a model of genotype-environment interactions in which the contribution of a particular allele to a quantitative character depends on the environment. Based on this model, they come to the conclusion that such mechanism " may be a potent force maintaining genetic variation in quantitative characters. " The purpose of this no...

2002
Warren J. Ewens Charles Langley James Crow

What are the observable consequences of randomness? This question has been asked in all disciplines where random processes affect significantly, or even entirely, those phenomena being studied. It arose in evolutionary genetics in the late 19605 when it was claimed that most of the genetic variation in natural populations, which was then being observed for the first time in detail, does not hav...

Journal: :Genetics and molecular research : GMR 2010
Z F Yang H W Cui T Hasi S Q Jia M L Gong X L Su

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyzed in 280 healthy unrelated Chinese Mongolian subjects, using a PCR-R...

2012
Inka Liesmaa Naotaka Shiota Jorma O. Kokkonen Petri T. Kovanen Ken A. Lindstedt

Accumulating work in experimental animals suggests that bradykinin (BK) exerts cardioprotective effects via bradykinin type-2 receptors (BK-2Rs). In human end-stage heart failure, BK-2Rs are significantly downregulated by mechanisms that have remained elusive. Heart tissues from idiopathic dilated cardiomyopathy (IDC; n = 7), coronary heart disease (CHD; n = 6), and normal patients (n = 6) were...

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