نتایج جستجو برای: allelic frequencies
تعداد نتایج: 109218 فیلتر نتایج به سال:
Research has shown that there are significant ethnic variations in the frequency of highly functional mutations in genes coding for metabolic enzymes. However, few studies have examined the frequency distribution of major allelic variations within the population of Iran. The present study focused on the genotype profile of southern Iranians in order to compare the allelic frequencies of CYP2C9,...
Background: Human essential hypertension has a genetic basis, and hypertension is associated with altered endothelial nitric oxide (NO) release. We hypothesized that functional alterations of the endothelium-derived NO pathway in the presence of the 894G>T polymorphism of the endothelial NO synthase (eNOS) gene may be related to circadian variation of blood pressure in patients with essential h...
conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...
BACKGROUND Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and continents examined the allelic frequencies of the nt230(del4) MDR1 mutation, emphasizing the clinical im...
In a recent paper by GILLESPIE and TURELLI (1 989), the authors suggest a model of genotype-environment interactions in which the contribution of a particular allele to a quantitative character depends on the environment. Based on this model, they come to the conclusion that such mechanism " may be a potent force maintaining genetic variation in quantitative characters. " The purpose of this no...
What are the observable consequences of randomness? This question has been asked in all disciplines where random processes affect significantly, or even entirely, those phenomena being studied. It arose in evolutionary genetics in the late 19605 when it was claimed that most of the genetic variation in natural populations, which was then being observed for the first time in detail, does not hav...
We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyzed in 280 healthy unrelated Chinese Mongolian subjects, using a PCR-R...
Accumulating work in experimental animals suggests that bradykinin (BK) exerts cardioprotective effects via bradykinin type-2 receptors (BK-2Rs). In human end-stage heart failure, BK-2Rs are significantly downregulated by mechanisms that have remained elusive. Heart tissues from idiopathic dilated cardiomyopathy (IDC; n = 7), coronary heart disease (CHD; n = 6), and normal patients (n = 6) were...
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