Herein, we developed a new procedure on 1,2-dicarbonylative cyclization of 4-aryl-1-butenes with alkyl bromides. Using simple copper catalyst, two molecules carbon monoxide were introduced into the double bond formation four C−C bonds and ring. Various α-tetralones 2,3-dihydroquinolin-4-ones formed in moderate to good yields.

Inert alkyl bromides are rarely used in photoinduced 1,2-difunctionalization of alkenes due to their strong reduction potential and bond dissociation energy. In Research Article (e202305121), Jin Xie co-workers overcome the inherent redox limit achieve 1,2-aminoalkylation 1,2-alkylarylation different by using inner single electron transfer mechanism an excited trinuclear gold catalyst.

Imidazolium salts are one of the most often used and investigated groups of ionic liquids (ILs). The research concerning their ecotoxicity comprised many test organisms representing different trophic levels; however, their impact on mixed cultures of microorganisms such as activated sludge has been hardly ever investigated. Thus, in this work, the effect of imidazolium ionic liquids on dehydrog...

Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via generation alkyl radicals from bromides and iodides. However, more stable chlorides remains challenging. Herein, we demonstrate excited-state palladium-catalyzed synthesis oxindoles isoquinolinediones alkylation/annulation reaction by overcoming inherent limitations associated with unac...

A mechanism that enables direct aldehyde C-H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C-H abstraction coupling technolo...

In drug discovery, the proportion of aliphatic carbons (C(sp3)) and presence chiral in organic molecules are positively correlated to their chance clinical success. Although methods exist for synthesis C(sp3)-rich molecules, they often limited scope, have poor modularity or unsuitable stereoselective using racemic reagents. The stereocontrol vicinal C(sp3) centres is a particular challenge. Her...