The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We als...

The rate of alveolar fluid clearance (AFC) is associated with mortality in clinical acute lung injury (ALI). Patients with ALI often develop circulatory shock, but how shock affects the rate of AFC is unknown. To determine the effect of circulatory shock on the rate of AFC in patients with ALI, the rate of net AFC was measured in 116 patients with ALI by serial sampling of pulmonary edema fluid...

Ras proteins are post-translationally modified by farnesylation. In the present investigation, we identified an activity in crude soluble extracts of yeast cells that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to yeast RAS2 protein. RAS2 proteins having a C-terminal Cys-Ali-Ali-Xaa sequence (where Ali is an aliphatic amino acid and Xaa is the unspecified C-terminal ...

Broad research interests and related applications: My research is in the area of stochastic systems, computational methods for sensing, estimation, and control problems, with a focus on robotic systems. In real-world systems, uncertainty (both in the system model and sensory readings) is omnipresent. A few of the vast set of applications for this research include (i) Motion planning for mobile ...

| 2017 | 1 Seyed-Hossein Abtahi1,2, Mohammad-Ali Abtahi1,2, Seyed Ali Akbar Mortazavi1,2, Hamidreza Jahanbani-Ardakani2,3,4, Mehdi Mazloumi5 1Department of Ophthalmology, School of Medicine, Isfahan University of Medical Sciences, 2Isfahan Eye Research Center, Isfahan University of Medical Sciences, 3Medical School, Isfahan University of Medical Sciences, 4Isfahan Medical Students Research Cent...

Acute lung injury (ALI) is a common and devastating illness that occurs in the context of sepsis and other systemic inflammatory disorders. In systemic illnesses like sepsis, only a subset of patients develops ALI even when pathologic stimuli are apparently equivalent, suggesting that there are genetic features that may influence its onset. Considerable obstacles in defining the exact nature of...

BACKGROUND Despite consensus criteria, diagnosing acute lung injury, or its more severe form acute respiratory distress syndrome (ALI/ARDS) remains challenging. Adding objective measures, such as plasma levels of biological markers could facilitate recognition of ALI/ARDS. This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-as...

Seawater drowning can lead to acute lung injury (ALI). Several studies have shown that bone marrow mesenchymal stem cells (BMSC) treatment could attenuate ALI. However, the mechanisms underlying this phenomenon still remain elusive. Therefore, this study aimed to investigate whether BMSC treatment can ameliorate seawater-induced ALI and its underlying mechanisms in a rat model. In this study, a...

Recently, the use of the algorithmic lateral inhibition (ALI) method in motion detection has shown to be very effective. The promising results in terms of the goodness of the silhouettes detected and tracked along video sequences lead us to accept the challenge of searching for a real-time implementation of the algorithms. This paper introduces two steps towards that direction: (a) A simplifica...

Acute limb ischemia (ALI) is a common vascular emergency. Hematologic malignancies are commonly associated with derangement of normal hemostasis and thrombo-hemorrhagic symptoms during the course of the disease are common. However, ALI as an initial presenting feature of acute leukemia is rare. Due to the rarity of this presentation, there is a scarcity of prospective randomized data to optimal...