Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial enzyme and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and the degradation of Acetylcholinesterase (AChE) the main pathologica...

The population-ecology approach (the natural-selection model) used to be a major orientation in consideration of organizational change and transformation. It is presented by its proponents as a theory distinct from structural contingency theory. This theory begins by rejecting the claim of contingency theory that organizations are adaptive. Contingency theory understands that the social and bus...

The primary education sector in Pakistan faces many challenges relating to access to education and quality of resources. This paper evaluates the Educational Voucher Scheme (EVS) in Lahore, Pakistan aimed at increasing access to primary schooling for low income families residing in the underdeveloped areas of Lahore by using the four criteria for evaluating privatization plans in education outl...

Neurotoxicity of beta-amyloid peptide (A beta) in Alzheimer's disease (AD) is usually thought to arise from the nonspecific effects of high concentrations of A beta on vulnerable neurons, resulting in membrane destabilization and increasing intracellular calcium concentration. This review advances the hypothesis that at early stages of AD, when A beta is present in lower amounts, its ability to...

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review manuscripts this issue. Many authors, regardless whether IJSSS publishes work, appreciate helpful feedback provided by reviewers. Their comments and suggestions were great help authors in improving quality papers. Each listed below returned at least one...

BACKGROUND Ventilator practices in patients at risk for acute lung injury (ALI) and ARDS are unclear. We examined factors associated with choice of set tidal volumes (VT), and whether VT < 8 mL/kg predicted body weight (PBW) relates to the development of ALI/ARDS. METHODS We performed a secondary analysis of a multicenter cohort of adult subjects at risk of lung injury with and without ALI/AR...

BACKGROUND The prognostic value of inflammation indexes in esophageal cancer has not been established. Recent studies have shown that the advanced lung cancer inflammation index (ALI) is a useful predictive factor. The purpose of the current study was to determine whether the ALI is useful for predicting long-term survival in patients with esophageal squamous cell carcinoma (ESCC). PATIENTS A...