Protein ligands were conjugated to the surface of biodegradable microspheres. These microsphere-ligand conjugates were then used in two in vitro model systems to evaluate the effect of conjugated ligands on microsphere behavior. Microsphere retention in agarose columns was increased by ligands on the microsphere surface specific for receptors on the agarose matrix. In another experiment, conjug...

background and objective: the opportunistic pathogen pseudomonas aeruginosa secrets a capsule-like polysaccharide called alginate which is important for evasion of host defenses, especially in patients with suppressed immunity. method of alginate determination has an important role in the study of microbial alginate. in this study, a novel method for alginate determination by highperformance li...

Carbon microsphere was successfully synthesized from waste office paper via hydrothermal method and high temperature treatment in nitrogen atmosphere. The process of carbon synthesis fiber using concentrated sulfuric acid studied, the influence H2SO4 concentration reaction time on hydrolysis considered. To investigate mechanism conversion to microsphere, Fourier transform infrared spectrometry ...

Simvastatin is demonstrated to be a potent stimulator for bone formation. However, a high dosage of simvastatin is required to induce bone regeneration in systematic administration, which may result in various side effects. Here we achieved the local administration of simvastatin through fabricating core/shell microspheres. Meanwhile, the addition of platelet derived growth factor (PDGF) encaps...

Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G). The polysaccharide is manufactured from brown algae where it constitutes the main structural cell wall polymer. The physical properties of a given alginate molecule, e.g., gel-strength, water-binding capacity, viscosity and biocompatibility, a...

Objective: The objective of this research was to formulate and evaluate pectin and HPMC different grades mucoadhesive microspheres in combination with sodium alginate for controlled release of maraviroc. Methods: The maraviroc mucoadhesive microspheres was successfully developed by Ionotropic gelation technique, using sodium alginate, pectin, HPMC K4, K15, and K100 as mucoadhesive polymer in va...

Four hydrophilic polymers in the form of beads - chitosan, alginate, alginate/polyvinyl alcohol (PVA), and chitosan-coated alginate - were used as supports for lipase immobilisation. Hydrogel beads were characterised by bead-size-distribution estimation, surface morphology studies, and polymer interactions assessment. Matrix performances - loading efficiency, immobilisation yield, enzyme activi...

We describe a method for creating alginate hydrogels with adjustable degradation rates that can be used as scaffolds for stem cells. Alginate hydrogels have been widely tested as three-dimensional constructs for cell culture, cell carriers for implantation, and in tissue regeneration applications; however, alginate hydrogel implants can take months to disappear from implantation sites because m...