Non-alcoholic fatty liver disease (NAFLD) which includes steatosis and steatohepatitis, in particular non-alcoholic steatohepatitis (NASH), is a rising health problem world-wide and should be separated from alcoholic steatohepatitis (ASH). NAFLD is regarded as hepatic manifestation of the metabolic syndrome (MetSy), being tightly linked to obesity and type 2 diabetes mellitus (T2DM). Developmen...

Non-alcoholic fatty liver disease (NAFLD) is emerging as one of the most common chronic liver diseases in developed western countries. Non-alcoholic steatohepatitis (NASH) is the most severe form of NAFLD, and can progress to more severe forms of liver disease, including fibrosis, cirrhosis, and even hepatocellular carcinoma. The activation of hepatic stellate cells plays a critical role in NAS...

Non-alcoholic fatty liver disease (NAFLD) may be present as simple steatosis and progress to non-alcoholic steatohepatitis (NASH). This inflammation of the liver tissue is a prerequisite to hepatic fibrosis and cirrhosis. NAFLD represents an important and common cause of liver disease worldwide. It is commonly associated with other medical problems such as obesity, cardiovascular disease, diabe...

Over the past decades, many drugs have been identified, that can potentially induce steatohepatitis in the predisposed individual. Classically this has been incriminated to amiodarone, perhexiline, and 4,4'-diethylaminoethoxyhexestrol (DH), all of which have been found to independently induce the histologic picture of non-alcoholic steatohepatitis (NASH). Pathogenetic mechanisms of hepatotoxici...

Abbreviations: HE: Hepatic Encephalopathy; PAMPs: Pathogen associated molecular patterns; TLRs: Toll-like Receptors; NLRs: Nodlike Receptors; LPS: Lipopolysacharide; HCV: Hepatitis C virus; CHB: Chronic Hepatitis B; HBV: Hepatitis B virus; ALD: Alcoholic Liver Disease; BM: Bone Marrow; NAFLD: Nonalcoholic Fatty Liver Disease; NASH: Non-alcoholic steatohepatitis; NO: Nitric Oxide; SIRS: Systemic...

the epidemic of obesity and associated features of metabolic syndrome including NASH (non-alcoholic steatohepatitis) and NAFld (non-alcoholic fatty liver disease) is spreading worldwide; thanks to the increasingly sedentary life style! it is estimated that 12-15% of the global population is affected with NAFld; 50% of diabetics develop NAFld. it is seen in 57-74% of obese persons and the preval...

The former is a sequel of acute viral hepatitis A and B, toxic hepatitis as a result of severe poisoning with hazardous substances or rapid blockage of the liver blood supply, while the latter one is an after-effect of chronic hepatitis B, C and autoimmune hepatitis, longterm alcohol abuse, disordered bile outflow, certain drugs administration, non-alcoholic fatty liver disease (NAFLD) and non-...

PETACH TIKVA, Israel, May 3, 2017 /PRNewswire/ -Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (TASE: CFBI), a biotechnology company with a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today provided an update on a Phase II clinical trial to evaluate its liver drug candidate Namodenoson (CF102) in the treatment of non-alcoholic fatty liver disease...

Non-alcoholic fatty liver disease (NAFLD) is by far the most common form of chronic liver disease worldwide, affecting adults as well as children. Under the term of NAFLD there is a wide spectrum of diseases ranging from simple steatosis to the non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma (HCC). Several mechanisms have been described to infl...