The burden of alcoholic liver disease continues to be a major public health problem worldwide. The spectrum of disease ranges from fatty liver to cirrhosis and hepatocellular carcinoma. Alcoholic hepatitis (AH) is a type of acute-on-chronic liver failure and the most severe form of alcoholic liver disease. Severe AH carries a poor short-term prognosis and its management is still challenging, w...

The dynamics and role of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and NKT cells in the life-threatening inflammatory disease alcoholic hepatitis is largely unknown. These cells directly kill infected and damaged cells through, e.g., degranulation and interferon-γ (IFNγ) production, but cause tissue damage if overactivated. They also assist tissue repair via IL-22 production. W...

Sera from patients with chronic liver disease were tested for antibody against hepatitis B surface antigen by radioimmunoassay. The antibody was found in 25% of patients with alcoholic cirrhosis and in 52% when alcoholic cirrhosis was associated with portal hypertension, these results being significantly higher than in a matched control population. Other forms of chronic liver disease did not d...

Gonadal function in male patients with various liver disease has been evaluated by basal plasma testosterone level and a response of plasma testosterone to human chorionic gonadotropin. Compared with healthy male subjects of similar age, gonadal function was not reduced in chronic hepatitis, but in alcoholic liver disease without cirrhosis and in alcoholic and non-alcoholic cirrhosis. Gonadal d...

aim : the aim of this study was to review cases of non-alcoholic fatty liver disease (nafld) cases and to determine the prevalence of non-alcoholic fatty liver disease as a cause of elevated alanine aminotransferase (alt) in healthy blood donors in the permian area and also assess risk factors of nafld such as body mass index (bmi) and correlation with metabolic syndrome in these subjects. back...

Scientific review covers current data regarding the role of quercetin in therapeutic corrections various liver diseases, particular non-alcoholic fatty disease, chronic hepatitis, drug-induced disease. The aim was to sum up scientific properties, its mechanism action and possibilities this flavonoid treatment diseases.Conclusions. Quercetin is found possess antioxidant, anti-inflammatory, hypol...

Severe alcoholic hepatitis is associated with high early mortality. This study aimed at identifying prognostic factors associated with in-hospital, medium- and long-term mortality of severe alcoholic hepatitis and to evaluate the different prognostic scoring systems on a cohort of patients in our hospital. To this end, we conducted a retrospective analysis of 66 episodes admitted between 2000 a...

Alcoholic liver disease, a leading cause of morbidity, mortality, and cirrhosis, can range from simple steatosis to hepatocellular carcinoma. Multiple mechanisms such as oxidative stress, mitochondrial dysfunction, and alteration in gut-liver axis have been proposed for the pathogenesis of alcoholic liver disease. Based on different prognostic models, alcoholic hepatitis patients can be stratif...

Clinical features of 52 patients with alcoholic hepatic diseases were described. Of these patients 27 had alcoholic hepatic cirrhosis. As compared with hepatic cirrhosis due to icteric viral hepatitis, vascular spider, ascites and edema were found more frequently in alcoholic cirrhosis. Hepatic biopsy showed preponderance of cirrhotic changes of postnecrotic type. Twenty-five patients had alcoh...

Peripheral blood and hepatic tissue T- and B-lymphocyte distributions, serum alpha fetoprotein (AFP) concentrations, and hepatic AFP were studied in 46 patients undergoing diagnostic percutaneous liver biopsy. The patients included 26 with alcoholic liver disease, 13 with nonalcoholic hepatitis or cirrhosis, and 7 with either normal histology or minor nonspecific changes. Serum AFP was determin...