Oxidative modifications are the hallmark of oxidative imbalance in the brain of individuals with Alzheimers, Parkinsons and Prion diseases and their respective animal models. The aim of the research was to study the impact of aluminum chloride (AlCl3) administration in drinking water (7mg/kg body weight) and Dgalactose(i.p).The results revealed that the levels of lipidperoxidation were signific...

The effect of morphine on amylase secretion was studied in isolated rat parotid acinar cells. It was found that aluminum fluoride (AlCl3/NaF) and dibutyryl-cyclic AMP but not by cyclic AMP, enhanced amylase secretion. Cyclic AMP was effective in enhancing secretion following permeabilization of cells with alpha-toxin. Following treatment of cells with alpha-toxin, both GTP and GTP-gamma-S also ...

Alzheimer's disease (AD) is a neurodegenerative clinically characterized by progressive cognitive impairment. This work aimed to investigate the role of quercetin (Q) in treatment and protection AlCl3-induced AD rats through exploring molecular mechanisms underlying its neuroprotective therapeutic properties. In this study, male Wistar were allocated two experiments: experiment I (therapeutic e...

BACKGROUND Alzheimer's disease (AD) is considered to be a neurodegenerative disorder that is characterized by increased oxidative stress. Medicinal plants, with their antioxidant properties, have been used to cure several human diseases. The aim of the current study was to explore the protective and therapeutic effect of baicalein on AD-induced rats. MATERIALS AND METHODS Swiss Wistar rats we...

Background: The Unani formulation Majun Brahmi (MB), a combination of herbs, is used in India as brain tonic and memory enhancer. Aluminium deposition the associated with development neurodegenerative diseases. Aims Objectives: present study was designed to observe that effects MB have been evaluated on aluminium trichlorideor chloride (AlCl3)-induced cognitive impairment an experimental rat mo...

In this study, the interference effects of Al3+, Mg2+, Cl- and SO4(2-) ions on the determination of manganese by graphite furnace atomic absorption spectrometry (GFAAS) were investigated. At first, the interferences caused by Al2(SO4)3, AlCl3, MgCl2 and MgSO4, which are the most possible major compounds for the combinations of the ions mixed, were individually considered. Then, the effects caus...

The present study was planned to investigate the ameliorative effects of α-lipoic acid (α-LA) supplementation against aluminium chloride (AlCl3) induced hepatotoxicity in rats. The results showed that rats consuming diets with AlCl3 added had poor growth performance, and most serum hematological indexes were significantly altered compared to the control. Biochemical results showed that lipid pe...

Haloarenes undergo direct borylation using amine : BCl3 : AlCl3 in the ratio of 1 : 1 : 2. After esterification the pinacol boronate esters are isolated in good yield with regioselectivity controlled by steric and electronic effects.