BACKGROUND Dipeptidyl peptidase-4 (DPP-4) inhibitors might have pleiotropic effects because receptors for incretin exist in various tissues, including liver. We examined whether DPP-4 inhibitors affect liver function in patients with type 2 diabetes. MATERIAL AND METHODS A retrospective review of 459 patients with type 2 diabetes who were prescribed DPP-4 inhibitors was performed. After exclu...

BACKGROUND Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transaminase (ALT) and Aspartate transaminase (AST). AIM Evaluating the potentiating effect of iron overload & viral hepatitis infection on the liv...

conclusions this report aimed to increase awareness of the occurrence of extra-intestinal systemic manifestations of rotavirus infection. although such cases may be rare, they still suggest that that rotavirus is a systemic viral infection. case presentations we report three pediatric cases of rotavirus infection: one accompanied by encephalopathy and two with elevated hepatic transaminase acti...

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. It encompasses a spectrum of conditions associated with lipid deposition in hepatocytes. It ranges from nonalcoholic steatohepatitis to advanced fibrosis and cirrhosis. The disease is mostly silent and is often discovered through incidentally elevated liver enzyme levels. It is strongly associate...

The liver is one of the organs involved in the multiorgan failure that occurs in sickle cell disease, the pathophysiology of liver disease in this condition is complex because of the interrelated multifactorial causes. Liver dysfunction was assessed in both paediatric and adult sickle cell disease patients in the steady state. The transaminases and alkaline phosphatase were analysed by automati...

The effects of oral feeding of aqueous extract of green tea leaf on alkaline phosphatase (ALP), acid phosphatase (ACP), alanine transaminase (ALT), aspartate transaminase (AST), sugar and total proteins were studied in the liver of cadmium treated rats. In cadmium control group sugar and protein levels were decreased and ALP level was significantly (p<0.001) decreased, whereas ACP, ALT and AST ...

Methods A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, Chongqing, China between March 2010 and April 2014 were retrospectively studied. Receiver operating characteristic (ROC) curves and area under ROC curves (AUROCs) were used to analyze the results of the models, which incorporated ageplatelet...

background the occult hepatitis b infection (obi) is defined as the presence of hepatitis b virus (hbv) dna in the sera or in the liver biopsy and the absence of hepatitis b surface antigen (hbsag) by serological test. objectives the current study aimed to evaluate the occult hbv infection by polymerase chain reaction (pcr) and determine hbv genotyping among the patients with abnormal alanine t...

Background: Non-alcoholic Fatty liver disease, also known as NAFLD is said to result from a number of disorders such insulin resistance, Obesity &amp; diabetes mellitus possibly an unhealthy and sedentary life style. The prevalence stated be 25.23%, but it ranges between 115 45% in Asian countries globally. Plasma aminotransferases (aspartate1aminotransferase [AST] alanine aminotransferase [ALT...

in this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from otostegia persica boiss (golder) was investigated against the carbon tetrachloride (ccl4)-induced acute hepatotoxicity in male rats. liver damage was induced through the oral administration of 50% ccl4 in liquid paraffin (2.5 ml/kg bw, per os) 60 min after the administration of the methanol extract o...