There are huge unmet medical needs in biliary tract cancer. Biliary cancer is non-rare Asia especially Korea. As a 1st-line chemotherapy, gemcitabine/cisplatin current standard of care, and 2nd-line setting, FOLFOX improved overall survival compared with best supportive care. heterogenous group not only primary origin but also molecular characteristics. Somatic alterations the KRAS, TP53, CDKN2...