Abstract BACKGROUND Mutations of the isocitrate dehydrogenase (IDH) gene are highly prevalent in WHO II/III glioma. IDH-mutated glioma frequently exhibits strong molecular signatures PI3K/AKT/mTOR signaling, whereas precise roles this oncogenic pathway remain elusive. METHODS In study, we performed unbiased RNA sequencing and set enrichment analysis (GSEA) to investigate relevant pathways gover...

The PI3K/Akt pathway plays a central role in a variety of cellular processes including cell growth, proliferation, motility and survival in both normal and tumor cells. The PI3K/Akt pathway is also instrumental in epithelial mesenchymal transitions and in angiogenesis during tumorigenesis. Many of the transforming events in breast cancer are a result of enhanced signaling of the PI3K/Akt pathwa...

Hepatocellular carcinoma (HCC) is the most common cancer of digestive system. Recently, transmembrane proteins (TMEMs) have been extensively studied in different types malignant tumors. However, influence TMEM206 hepatocellular unclear. The UALCAN database was used to investigate expression mRNA liver tissues and Human Protein Atlas (THPA) study HCC tissues. measured normal HL-7702 cells HepG2,...

Abstract Background and Aims Chronic kidney disease (CKD) represents a significant public health burden worldwide, mainly driven by the increase of incidence associated risk factors like diabetes. Decreased renal Klotho expression is an early feature CKD, driving on circulating FGF23 phosphate. These alterations in mineral metabolism have direct negative impact progression dysfunction can cause...

Activation of the AKT (serine-threonine kinase) pathway is a common feature in glioblastoma cells. Downstream factors of the AKT pathway are involved in cell proliferation, apoptosis, cellular migration and angiogenesis. Micro-RNAs (miRNAs) are highly conserved small non-coding RNAs that block targeted mRNA expression at the post-transcriptional level. The aim of this study was to investigate t...

Background Liver cancer is a common threat to human health. Schizandrin A (SA) has certain therapeutic effect on liver cancer, but its related mechanism of action not clear. Elucidating this great significance for the development drugs target cancer. Objective The objective study and SA Methods potential targets in treatment were screened based network pharmacology, core further by protein inte...

Purpose: To investigate the effect of Qibai Pingfei capsules (QBPF) medicated serum on apoptosis rat pulmonary artery smooth muscle cells (PASMC) in hypoxic rats, and to determine relationship between that PI3K/Akt/mitochondrial pathway.Methods: Rat PASMCs were isolated, cultured, optimal time concentration QBPF determined by CCK-8 method. Hypoxic rats treated with QBPF, + LY294002, or SC79. Ap...

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, cytok...

Motoneurons require neurotrophic factors for their survival and axonal projection during development, as well as nerve regeneration. By using the axotomy-induced neuronal death paradigm and adenovirus-mediated gene transfer, we attempted to gain insight into the functional significances of major growth factor receptor downstream cascades, Ras-extracellular signal-regulated kinase (Ras-ERK) path...