Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by recognizing the proteins in this pathway. The st...

Telomerase reverse transcriptase (TERT) vectors were transfected into bone marrow mesen- chymal stem cells (BMSCs) which then cultured and selected to establish TERT-BMSC cell lines whilst sequencing BMSCs TERT-BMSCs via transcriptome in this study explore their regulatory mechanism effect on osteogenic differentiation after TERT ectopic expres- sion sheep BMSCs. After analysing differential ge...


 Purpose: To study the effect of dexmedetomidine (Dex) on AKTERK signaling pathway and EMT- related proteins in high glucose-induced apoptosis human kidney tubular epithelial cells.
 Methods: HK-2 cells were assigned to control, high-glucose Dex groups. Levels ROS determined using live cell station. Flow cytometry was used measure cycle while Western blot applied assay levels PI3K, A...

background: acute lymphoblastic leukemia (all), the most common childhood cancer with a peak incidence in children from 2-5 years old, might be associated with poor prognosis and resistance to therapy in specific cytogenetic backgrounds. foxo3a, a member of the forkhead class 'o' (foxo) transcription factors, is a main downstream target of pi3k/akt pathway which regulates different variety of b...

conclusions in conclusion, ctp-hbcag18-27-tapasin could reduce apoptosis of cd8+ t cells, increase the percentages of ifn-γ+ cd8α+ t cells, and elicit cell-mediated immunity in hla-a2 transgenic mice; these processes were associated with activation of the pi3k/akt signaling pathway. results the results showed that ctp-hbcag18-27-tapasin significantly increased the percentages of ifn-γ+ cd8α+ t ...

The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix me...

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity. Emerging novel drugs aim to regulate the anti-tumor immune response by activating anti-diabetic drug metformin has been reported exhibit anti-cancer effect against various types of cancer. However, gastric cancer remains unknown. In our study, we first used bioinformatic analysis detect that is closely related ...

the lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. however in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. the metastasis of lung cancer is highly dependent of expression of matrix me...

Objective(s): The current study was aimed to investigate the effect of morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) on ipsilateral epididymis injury in a rat model of experimental varicocele (VC).Materials and Methods: Sixty Wistar rats were randomly assigned to sham, sham plus GYY4137, VC and VC plus GYY4137...