نتایج جستجو برای: airway remodeling

تعداد نتایج: 136490  

Journal: :Journal of applied physiology 2011
Elizabeth L Kramer William D Hardie Elizabeth M Mushaben Thomas H Acciani Patricia A Pastura Thomas R Korfhagen Gurjit Khurana Hershey Jeffrey A Whitsett Timothy D Le Cras

Airway hyperreactivity (AHR) and remodeling are cardinal features of asthma and chronic obstructive pulmonary disease. New therapeutic targets are needed as some patients are refractory to current therapies and develop progressive airway remodeling and worsening AHR. The mammalian target of rapamycin (mTOR) is a key regulator of cellular proliferation and survival. Treatment with the mTOR inhib...

2013
Su Xu Bao-Ping Tian Lan-Hong Zhang Wen Hua Li-Xia Xia Zhi-Hua Chen Wen Li Hua-Hao Shen

BACKGROUND Astragali radix Antiasthmatic Decoction (AAD), a traditional Chinese medication, is found effective in treating allergic diseases and chronic cough. The purpose of this study is to determine whether this medication could suppress allergen-induced airway hyperresponsiveness (AHR) and remodeling in mice, and its possible mechanisms. METHODS A mouse model of chronic asthma was used to...

2013
Zhuang-Gui Chen Tian-Tuo Zhang Hong-Tao Li Fen-Hua Chen Xiao-Ling Zou Jing-Zhi Ji Hong Chen

Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. However, the initiating factor that links airway inflammation to remodeling is unknown. Thymic stromal lymphopoietin (TSLP), an epithelium-derived cytokine, can strongly activate lung dendritic cells (DCs) through the TSLP-TSLPR and OX40L-OX40 signalin...

Journal: :American journal of respiratory and critical care medicine 2001
L M van den Toorn S E Overbeek J C de Jongste K Leman H C Hoogsteden J B Prins

Symptoms of atopic asthma often disappear at puberty. However, asthmatic subjects in clinical remission will frequently have a relapse later in life. The aim of this study was to investigate whether subjects in clinical remission of atopic asthma have persistent airway inflammation and/or airway remodeling. Bronchial biopsies were obtained from subjects in clinical remission, asthmatic subjects...

2017
Anudeep Kota Deepak Deshpande Mehra Haghi Brian Oliver Pawan Sharma

In the past decade, an emerging process named "autophagy" has generated intense interest in many chronic lung diseases. Tissue remodeling and fibrosis is a common feature of many airway diseases, and current therapies do not prevent or reverse these structural changes. Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components to maintain basal cel...

2011
Carla M. Prado Mílton A. Martins Iolanda F. L. C. Tibério

Asthma is a chronic inflammatory airway disease characterized by allergen-induced airway hyperresponsiveness, airway inflammation, and remodeling. Nitric oxide (NO) derived from constitutive and inducible enzymes affects many aspects of asthma physiopathology. Animal in vivo studies have indicated that inhibition of iNOS may play a central role in the modulation of these features, particularly ...

Journal: :Molecular pharmacology 2017
Musaddique Hussain Chengyun Xu Mashaal Ahmad Youping Yang Meiping Lu Xiling Wu Lanfang Tang Ximei Wu

Lung development is mediated by assorted signaling proteins and orchestrated by complex mesenchymal-epithelial interactions. Notch signaling is an evolutionarily conserved cell-cell communication mechanism that exhibits a pivotal role in lung development. Notably, both aberrant expression and loss of regulation of Notch signaling are critically linked to the pathogenesis of various lung disease...

Journal: :Clinical immunology 2013
Kwang Je Baek Jae Youn Cho Peter Rosenthal Laura E Crotty Alexander Victor Nizet David H Broide

Whether hypoxia contributes to airway inflammation and remodeling in asthma is unknown. In this study we used mice exposed to a hypoxic environment during allergen challenge (simulating hypoxia during an asthma exacerbation) to investigate the contribution of hypoxia to airway inflammation and remodeling. Although neither hypoxia alone, nor OVA allergen alone, induced significant neutrophil inf...

Journal: :Journal of immunology 2011
Amanda L Tatler Alison E John Lisa Jolly Anthony Habgood Jo Porte Chris Brightling Alan J Knox Linhua Pang Dean Sheppard Xiaozhu Huang Gisli Jenkins

Severe asthma is associated with airway remodeling, characterized by structural changes including increased smooth muscle mass and matrix deposition in the airway, leading to deteriorating lung function. TGF-β is a pleiotropic cytokine leading to increased synthesis of matrix molecules by human airway smooth muscle (HASM) cells and is implicated in asthmatic airway remodeling. TGF-β is synthesi...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Dae Hyun Lim Jae Youn Cho Marina Miller Kirsti McElwain Shauna McElwain David H Broide

Matrix metalloproteinases (MMPs) are a family of extracellular proteases that are responsible for the degradation of the extracellular matrix during tissue remodeling. We have used a mouse model of allergen-induced airway remodeling to determine whether MMP-9 plays a role in airway remodeling. MMP-9-deficient and wild-type (WT) mice were repetitively challenged intranasally with ovalbumin (OVA)...

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