نتایج جستجو برای: aia

تعداد نتایج: 1020  

2009
Sun-Hee Oh Se-Min Park Jong-Sook Park An-Soo Jang Yong-Mok Lee Soo-Taek Uh Young Hoon Kim In-Seon Choi Mi-Kyeong Kim Byeong Lae Park Hyoung-Doo Shin Choon-Sik Park

PURPOSE Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors activated by ligands of the nuclear hormone receptor superfamily. The activation of PPARgamma regulates inflammation by downregulating the production of Th2 type cytokines and eosinophil function. In addition, a range of natural substances, including arachidonate pathway metabolites such as 15-hydroxyeicosat...

Journal: :Journal of immunology 2008
Shiva Shahrara Amanda E I Proudfoot Christy C Park Michael V Volin G Kenneth Haines James M Woods Christopher H Aikens Tracy M Handel Richard M Pope

Chemokines, including RANTES/CCL5 and MCP-1/CCL2, are highly expressed in the joints of patients with rheumatoid arthritis, and they promote leukocyte migration into the synovial tissue. This study was conducted to determine whether the inhibition of RANTES and MCP-1 therapeutically was capable of ameliorating rat of adjuvant-induced arthritis (AIA). Postonset treatment of AIA using a novel inh...

2016
E. Matthew Hoffman Zijia Zhang Ruben Schechter Kenneth E. Miller

Glutamate is a neurotransmitter used at both the peripheral and central terminals of nociceptive primary sensory neurons, yet little is known concerning regulation of glutamate metabolism during peripheral inflammation. Glutaminase (GLS) is an enzyme of the glutamate-glutamine cycle that converts glutamine into glutamate for neurotransmission and is implicated in producing elevated levels of gl...

Journal: :Journal of immunology 2002
Akihisa Yamashita Yoshikazu Yonemitsu Shinji Okano Kazunori Nakagawa Yutaka Nakashima Takahiko Irisa Yukihide Iwamoto Yoshiyuki Nagai Mamoru Hasegawa Katsuo Sueishi

Rheumatoid arthritis (RA), a systemic inflammatory disease of unknown etiology, mainly affects synovial joints. Although angiogenic growth factors, including fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF), may play a critical role in the development and progression of RA joint disease, little information is now available regarding their exact role in initiation...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Yoichi Shinkai Yuta Yamamoto Manabi Fujiwara Takashi Tabata Takashi Murayama Takaaki Hirotsu Daisuke D Ikeda Makoto Tsunozaki Yuichi Iino Cornelia I Bargmann Isao Katsura Takeshi Ishihara

Animals facing conflicting sensory cues make a behavioral choice between competing alternatives through integration of the sensory cues. Here, we performed a genetic screen to identify genes important for the sensory integration of two conflicting cues, the attractive odorant diacetyl and the aversive stimulus Cu(2+), and found that the membrane-bound guanylyl cyclase GCY-28 and the receptor ty...

Journal: :Arthritis and rheumatism 2005
Christian S Haas Rita J Martinez Naweah Attia G Kenneth Haines Phillip L Campbell Alisa E Koch

OBJECTIVE Chemokine receptors mediate leukocyte migration into inflamed rheumatoid arthritis (RA) synovial tissue (ST). Knowledge of their distribution is crucial for understanding the evolution of the inflammatory process. In this study, we used rat adjuvant-induced arthritis (AIA), a model for RA, to define the temporospatial expression of chemokine receptors. METHODS ST from rats with AIA ...

2012
Clément Prati Alain Berthelot Bernadette Kantelip Daniel Wendling Céline Demougeot

INTRODUCTION Endothelial dysfunction (ED) participates to atherogenesis associated to rheumatoid arthritis. We recently reported increased arginase activity/expression in vessels from adjuvant-induced arthritis (AIA) rats. In the present study, we investigated the effects of a curative treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine (nor-NOHA) on vascular dysfunction in AIA rats...

Journal: :BMB reports 2010
Byung-Lae Park Se-Min Park Jong-Sook Park Soo-Taek Uh Jae-Sung Choi Yong-Hoon Kim Mi-Kyeong Kim Inseon S Choi Byoung-Whui Choi Sang-Heon Cho Chein-Soo Hong Yong-Won Lee Jae-Young Lee Choon-Sik Park Hyoung-Doo Shin

Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After ...

Journal: :Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2016
Suleyman Sahin Fatih Karatas Ali R Sever Kadri Altundag

Aromatase inhibitors (AIs) are standard of care in the adjuvant setting of postmenopausal women with hormone receptor positive breast cancer. Despite their beneficial effects on survival outcomes in breast cancer, AIs-induced arthralgia (AIA) is a common side effect which may lead to drug discontinuation and decreased AIs adherence among patients. So far, the exact pathophysiology of AIA is sti...

Journal: :Annals of the rheumatic diseases 1999
J B van Meurs P L van Lent A A van de Loo A E Holthuysen E K Bayne I I Singer W B van den Berg

OBJECTIVE Murine antigen induced arthritis (AIA) is a chronic, smouldering inflammation. Flares of arthritis can be induced by antigen rechallenge or exposure to inflammatory mediators like interleukin 1 (IL1). These flares are characterised by a fast and marked proteoglycan (PG) depletion if compared with the initial arthritis. This study investigated the involvement of metalloproteinases in b...

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