نتایج جستجو برای: agrp عضله

تعداد نتایج: 3660  

Journal: :Cell 2012
Hongxia Ren Ian J. Orozco Ya Su Shigetomo Suyama Roger Gutiérrez-Juárez Tamas L. Horvath Sharon L. Wardlaw Leona Plum Ottavio Arancio Domenico Accili

Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so. FoxO1 is a shared mediator of both pathways, and its inhibition is required to induce satiety. ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه فردوسی مشهد - پژوهشکده تربیت بدنی و علوم ورزشی 1391

مقدمه: agrp یا پروتئین وابسته به آگوتی یک نروپپتاید اشتها آور است که موثر در رفتار دریافت غذا، انتخاب غذا، تنظیم وزن، هموستاز انرژی و چاقی می باشد و سطح آن هنگام روزه داری، هیپوگلیسیمی(کم قندی) و چاقی بالا می رود. هدف از تحقیق حاضر مقایسه اثر یک جلسه تمرین مقاومتی دایره ای و تمرین هوازی بر بیان ژن agrp لنفوسیت زنان جوان تمرین کرده می باشد. روش تحقیق: 24 زن تمرین کرده به طور داوطلبانه انتخاب و...

Journal: :Environmental Health Perspectives 1996
M Ma

Agouti-related protein encodes a neuropeptide that stimulates food intake. Agrp expression in the brain is restricted to neurons in the arcuate nucleus of the hypothalamus and is elevated by states of negative energy balance. The molecular mechanisms underlying Agrp regulation, however, remain poorly defined. Using a combination of transgenic and comparative sequence analysis, we have previousl...

Journal: :Endocrinology 2004
Christopher B Kaelin Allison Wanting Xu Xin-Yun Lu Gregory S Barsh

Agouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation. We tested a series of bacterial artificial chromosome repo...

Journal: :Neuron 2016
Dong Kong Yossi Dagon John N. Campbell Yikun Guo Zongfang Yang Xinchi Yi Pratik Aryal Kerry Wellenstein Barbara B. Kahn Bernardo L. Sabatini Bradford B. Lowell

AMP-activated protein kinase (AMPK) plays an important role in regulating food intake. The downstream AMPK substrates and neurobiological mechanisms responsible for this, however, are ill defined. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus regulate hunger. Their firing increases with fasting, and once engaged they cause feeding. AgRP neuron activity is regulated by ...

Journal: :The EMBO journal 2012
Luis Varela Tamas L Horvath

AgRP/NPY neurons are critical regulators of body weight and food intake. Concordant with their orexigenic effects, it is expected that AgRP ablation leads to the appearance of a lean phenotype. In the current issue of The EMBO Journal, Joly-Amado et al (2012) describe an obese phenotype in a model of AgRP-ablated mice, and link it to a shift in metabolic profile in efferent tissues such as the ...

2016
Ken-ichiro Nakajima Zhenzhong Cui Chia Li Jaroslawna Meister Yinghong Cui Ou Fu Adam S. Smith Shalini Jain Bradford B. Lowell Michael J. Krashes Jürgen Wess

Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling properties, including Gs-linked GPCRs. At present, the potential role of Gs-coupled GPCRs in regulating the ...

Journal: :Cell 2015
Sophie M. Steculorum Lars Paeger Stephan Bremser Nadine Evers Yvonne Hinze Marco Idzko Peter Kloppenburg Jens C. Brüning

Activation of orexigenic AgRP-expressing neurons in the arcuate nucleus of the hypothalamus potently promotes feeding, thus defining new regulators of AgRP neuron activity could uncover potential novel targets for obesity treatment. Here, we demonstrate that AgRP neurons express the purinergic receptor 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK phosphory...

Journal: :iranian journal of basic medical sciences 0
fatemeh sabet sarvestani infertility research center, shiraz university of medical sciences, shiraz, iran amin tamadon infertility research center, shiraz university of medical sciences, shiraz, iran transgenic te.chnology research center, shiraz university of medical sciences, shiraz, iran aida hematzadeh transgenic technology research center, shiraz university of medical sciences, shiraz, iran maliheh jahanara transgenic technology research center, shiraz university of medical sciences, shiraz, iran mohammad reza jafarzadeh shirazi department of animal sciences, college of agriculture, shiraz university, shiraz, iran ali moghadam biotechnology institute, college of agriculture, shiraz university, shiraz, iran

objective: melanocortin-4 receptor (mc4r) and agouti-related peptide (agrp) are involved in energy homeostasis in the rat. the aim of the present study was to evaluate the expression of mc4r and agrp mrnas in arcuate nucleus (arc) during long term malnutrition of female ovariectomized rats. materials and methods: ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...

Journal: :Endocrinology 2000
J Korner S L Wardlaw S M Liu I M Conwell R L Leibel S C Chua

Agouti-related protein provides an orexigenic signal, probably through interaction with central melanocortin receptors. Expression of Agrp is markedly increased in the hypothalamus of mice deficient in leptin (Lep(ob)/Lep(ob)) or its receptor (Lepr(db)/Lepr(db)), suggesting that leptin mediates signals suppressing Agouti-related protein production. The regulation of Agrp expression in the rat h...

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