Pisinger et al. introduced the concept of ‘aggressive reduction’ for large-scale combinatorial optimisation problems. The idea is to spend much time and effort in reducing the size of the instance, using information obtained from a sequence of fast lowerand upper-bounding procedures. The hope is that the reduced instance will then be small enough to be solved by an exact algorithm. We present a...

The present study sought to elucidate the prognosis of adult T-cell leukemia-lymphoma (ATL) patients receiving mogamulizumab, a defucosylated anti-CCR4 monoclonal antibody. Progression-free survival (PFS) and overall survival (OS) of ATL patients enrolled in two studies are herein updated, namely NCT00355472 (phase I study of mogamulizumab in relapsed patients with ATL and peripheral T-cell lym...

Background and Objective: Clinical behavior of basal cell carcinoma (BCC) is known to be different according to histological growth pattern and basosquamous cell carcinomas (BSC) are known with their aggressive behavior and metastatic capacity. In this study, we evaluated bcl-2 and cyclin D1 expressions in BCC and BSC cases comparatively, to explore their predictive value on the aggres...

objective: aggression is a disruptive behavior that limits children’s ability for a better adjustment. as commonly reported, sleep problems is associated with the presentation of aggression in adhd children. in this study, we aimed to investigate the association between sleep problems and aggressive behavior in children with adhd.  methods: the study method is correlational and cross-sectional....

Cardiac output (with cardiogreen dye dilution), heart rate, stroke volume, mean arterial pressure, and central venous pressure (SVC) were measured': I) following induction of anesthesia while the abdomen was being opened, 2) during mobilization of the recipient'S liver, 3) shortly following cross-clamping the inferior vena cava and portal vein (early anhepatic phase), 4) just prior to revascula...

OBJECTIVE To test the effects of technique and attitude in pulling Christmas crackers. DESIGN, SETTING AND PARTICIPANTS A binomial trial conducted at a Christmas-in-July dinner party involving five anonymous dinner guests, including two of the authors. MAIN OUTCOME MEASURE Number of wins achieved by different strategies, with a win defined as securing the larger portion of the cracker. RE...