Affine spheres were introduced by Ţiţeica in [72, 73], and studied later by Blaschke, Calabi, and Cheng-Yau, among others. These are hypersurfaces in affine R which are related to real Monge-Ampère equations, to projective structures on manifolds, and to the geometry of Calabi-Yau manifolds. In this survey article, we will outline the theory of affine spheres their relationships to these topics...