OBJECTIVE To assess the effects of a selective serotonin reuptake inhibitor on semen parameters. DESIGN Prospective study. SETTING Academic medical center. PATIENT(S) Thirty-five healthy male volunteers, 18-65 years old. INTERVENTION(S) Paroxetine administration for 5 weeks. MAIN OUTCOME MEASURE(S) Serum hormone levels, semen analyses, percent sperm DNA fragmentation, and questionnair...

PATIENT Male, 81 FINAL DIAGNOSIS: Prostate cancer Symptoms: Anorexia • dark urine • joundice • letargy MEDICATION Casodex Clinical Procedure: - Specialty: Oncology. OBJECTIVE Adverse events of drug therapy. BACKGROUND Bicalutamide is a nonsteroidal anti-androgen used extensively during the initiation of androgen deprivation therapy with a luteinizing hormone-releasing hormone (LHRH) agoni...

This paper evaluates procedures relevant to extrapolating from toxicity data in man and animals to Occupational Exposure Limits. It examines effects at or around the "No Observed Adverse Effect Level' (NOAEL) and the magnitude of safety factors which can be applied in developing occupational exposure limits for non-stochastic effects. The relationship between incidence of stochastic effect and ...

Unexpected adverse preclinical findings (APFs) are not infrequently encountered during drug development. Such APFs can be functional disturbances such as QT prolongation, morphological toxicity or carcinogenicity. The latter is of particular concern in conjunction with equivocal genotoxicity results. The toxicologic pathologist plays an important role in recognizing these effects, in helping to...

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Dimethomorph Chemical Code # 4003, Tolerance # 52068 SB 950 # New A.I. 6/01/01 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, possible adverse effect Oncogenicity, mouse: No data gap, no adverse ef...

stem cell therapy could have great potential for the treatment of a wide variety of diseases. stem cells might have the ability to differentiate into a widespread cell types, and to repopulate and revitalize the damaged cells with healthy tissue, and improve its performance. we provide here the evidence supporting the critical use of stem cell as a treatment in disease conditions existing with ...

Background and Objectives: Studies have shown that patients awaiting coronary angiography (CA) are often anxious. High level of anxiety can lead to physical and psychological stress with adverse effects on organs, es‌pecially heart. There is limited information on state and trait anxiety level in these patients in the literature. This study was thus designed to investigate the level of these tw...

Drug-drug interactions (DDIs) can lead to increased toxicity or reduction in therapeutic efficacy. This study was designed to assess the incidence of potential drug interactions (PDI) and rank their clinical value in post coronary care unit (Post-CCU) of a teaching hospital in Tehran, Iran.In this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

Drug-drug interactions (DDIs) can lead to increased toxicity or reduction in therapeutic efficacy. This study was designed to assess the incidence of potential drug interactions (PDI) and rank their clinical value in post coronary care unit (Post-CCU) of a teaching hospital in Tehran, Iran.In this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

Here in this paper, we report a 31-year-old case admitted with symptoms of hyperthyroidism that was then diagnosed with Grave's disease (GD) and underwent treatments with a low dosage of methimazole (10 mg/day). 20 days after treatments initiations, she developed antithyroid arthritis syndrome. This patient experienced arthritis and arthralgia in at least 4 joints. And all autoimmune and microb...