We present a patient with hypertension and hypokalemia secondary to an aldosterone-producing adenoma that was renin responsive (APARR). We discussed the sequential approach to the diagnosis of the different subtypes of primary aldosteronism and confirmed the presence of an APARR. The most common cause of primary aldosteronism is an aldosteronoma; functionally, these adenomas respond poorly to a...

psoriasis is a chronic, non-contagious skin condition characterized by inflamed and scaly lesions of skin. whilst the pathogenesis of psoriasis is not known, psychological stress has been implicated as a potential trigger in the onset and exacerbation of the condition. psychiatric and psychological factors play an important role in at least 30% of dermatologic disorder and pathophysiologic link...

Adenyl cyclase and cyclic 3’,5’-nucleotide phosphodiesterase were shown in homogenates of bovine corpora lutea. In order to determine the site of action of luteinizing hormone, the adenyl cyclase activity was assessed in the absence of phosphodiesterase activity. This was accomplished by using a high concentration of theophylline and short incubation periods. Under these conditions, luteinizing...

Protostomes and Deuterostomes show the same nexus between melanin production, and amyloid fibril production, i.e., the presence of melanin is indissolubly linked to amyloid scaffold that, in turn, is conditioned by the redox status/cytoplasmic pH modification, pro-protein cleavage presence, adrenocorticotropin hormone (ACTH), melanocyte-stimulating hormone (α-MSH), and neutral endopeptidase (NE...

The structures of three polypeptide hormones (glucagon, a 25-residue analogue of adrenocorticotropin, and parathyroid hormone) which contain enough residues to permit organization have been evaluated in aqueous solution by fluorescence and circular dichroism. The effects of pH, temperature, and guanidine on both tyrosyl and tryptophanyl emission have been measured. None of the fluorescence para...

Proopiomelanocortin (POMC) plays an essential role in the stress response of the hypothalamic-pituitary-adrenal axis, and is the precursor of biologically active peptides such as adrenocorticotropin (ACTH), alpha-melanocyte-stimulating hormone (alpha-MSH), beta-melanocyte-stimulation hormone (beta-MSH) and beta-endorphin. We have synthesized two different forms of POMC cDNA clones, POMC-I and P...

In a study of 102 women (Arabs and Asians) with hirsutism, polycystic ovary syndrome was diagnosed in 93 patients (91%) including 26 cases with hirsutism and regular menstrual periods. In more than half of the cases the diagnosis was made on the basis of transabdominal ultrasonography, which was the single test with the highest yield. Luteinising hormone hyperresponsiveness to gonadotropin-rele...

Although ethanol has been considered to be an anxiolytic agent, consumption of ethanol has also been shown to increase plasma adrenocorticotropin and glucocorticoids. The corticotrophin-releasing factor (CRF) receptor 1alpha (CRF-R1) is a G protein-coupled receptor that activates adenylyl cyclase (AC), leading to adrenocorticotropin (and subsequently glucocorticoid) release into the circulation...

cushing’s syndrome (cs) occurs rarely during pregnancy. cs can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. it is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. in thi...