PURPOSE We have reported previously nonsense inactivating mutations of the phosphodiesterase 11A (PDE11A) gene in patients with micronodular adrenocortical hyperplasia and Cushing syndrome. The aim of this study is to investigate the presence of somatic or germ-line PDE11A mutations in various types of adrenocortical tumors: ACTH-independent macronodular adrenocortical hyperplasia (AIMAH), adre...

The paper discusses relations between the structure of the complex Fermi surface below the spectrum of a second order periodic elliptic equation and integral representations of certain classes of its solutions. These integral representations are analogs of those previously obtained by S. Agmon, S. Helgason, and other authors for solutions of the Helmholtz equation (i.e., for generalized eigenfu...

adrenocortical carcinomas (acc) is an uncommon disease that accounts for only 0.02% of all cancers. herein, this study evaluates a case of adult acc with extension into the inferior vena cava and cushingoid features. a 67-year-old lady was admitted to the surgery service for surgical resection of adrenal mass which was found on hypertension work-up. on physical examination, she was fat, cushing...

HYPOTHESIS The gene expression profiles of benign and malignant adrenocortical tumors are different. DESIGN Genomewide gene expression profiling and validation. SETTING Tertiary medical center. PATIENTS Eighty-five patients with benign adrenocortical tumors (n = 74) and adrenocortical carcinoma (n = 11). INTERVENTION Real-time quantitative reverse transcription-polymerase chain reaction...

Using immunoperoxidase methods, 94 human adrenal tumors were examined for evidence of immunoreactivity and receptor expression of insulinlike growth factor I (IGF-I) and insulin. The frequency of IGF-I in adrenocortical carcinomas was significantly higher than that in adenomas of the adrenal glands. The adrenocortical carcinomas showed strong intensity of staining for IGF-I, IGF-I receptors, an...

Although adrenocortical tumors are common, adrenocortical carcinomas are rare. Moreover, aldosterone-producing adrenocortical carcinomas without hypertension are exceedingly rare, with only two previously reported cases.

Adrenocortical cancer is an orphan tumor with poor prognosis. The combination of EDP chemotherapy regimen and mitotane the standard for first‑line therapy. But there are no effective options second consequent lines second‑line therapy gemcitabine, capecitabine mitotane, which provides objective response in 4–7 % patients. Achievement therapeutic concentration most important predictive factor ef...

Autonomously Functioning Thyroid Nodule (AFTN) is a rare cause of hyperthyroidism. AFTN, first described by Emil Goetsch in 1918, the presence single hyperfunctioning thyroid nodule, which not under control pituitary/thyroid axis. The current theory on development nodules constitutive activation Stimulating Hormone Receptor (TSHR) due to somatic point mutation and mutations Gsa. reported incide...

Disorders of the endocrine system including hormone hyperfunction and hypofunction have multiple effects on cardiovascular system. However, in clinical practice, there are many cases of delayed or overlooked diagnosis of underlying endocrine dysfunction in patients presenting chest pain or other cardiac symptoms. Herein, we report three cases of endocrine hyperfunction presenting as coronary sp...