Presentations at previous Reciprocal Meat Conferences (Ricks et al., 1984; Beermann et al., 1985) and the presentations immediately preceding mine have described in detail the influence of p-adrenergic agonists, such as clenbuterol, cimaterol or ractopamine, on growth and carcass traits in livestock. We now can say with some certainty that the feeding of p-adrenergic agents to livestock increas...

Antibodies were raised against a newly synthesized analog (CP57,609) of the alpha 1-selective antagonist prazosin, and against the alpha 2-selective antagonist, yohimbine, by immunization of rabbits with antigens prepared by covalent linkage of these ligands to albumin. Competitive inhibition of [3H]prazosin binding to anti-CP57,609 antiserum by a variety of unlabeled ligands revealed a spectru...

Adrenergic beta-blocking agents were given to 7 patients with advanced congestive cardiomyopathy who had tachycardia at rest (98 plus or minus 13 beats/min). The patients were on beta-adrenergic receptor blockade for 2 to 12 months (average 5-4 months). One patient was given alprenolol 50 mg twice daily and the other patients were given practolol 50 to 400 mg twice daily. Virus infection had oc...

THE EFFECTS of stimulation of the cardiac sympathetic nerves and of circulating catecholamines on the heart and coronary circulation have been studied extensively for more than 80 years. The biochemical, electrophysiological, and mechanical responses of the myocardium have been described in considerable detail but surprisingly little is known about the adrenergic responses of the coronary vesse...

Practolol was administered in 47 instances of acute arrhythmia, mainly of supraventricular origin. The drug was highly effective in 75 per cent of cases, including those with acute myo-cardial infarction. The therapeutic dose ranged from 5 to I8o mg. Despite administration of doses up to 500 mg, no serious side effects were noted. The beta-adrenergic blocking agents are gaining increasingly wid...

Alpha- and beta-adrenergic blocking agents and imipramine inhibit the increased hyaluronate synthesis that may be induced in human synovial cultures by connective tissue activating peptide (CTAP). Considerations of drug concentration requirements, actions of analogues, and time studies all indicate that the adrenergic blockers do not act in this circumstance as conventional blockers of alpha or...