Poly(ADP-ribosylation) is a post-translational modification of proteins involved in a wide range of molecular and cellular processes in mammalian system. The main enzymes responsible for this modification are the poly(ADP-ribose) polymerases that catalyze the transfer of ADP-ribose moieties from NAD + to target protein acceptors, producing long and branched ADP-ribose polymers. The poly(ADP-rib...

This paper reviews recent progress in model identification-based learning and optimal control its applications to multi-agent systems (MASs). First, a class of learning-based method, namely adaptive dynamic programming (ADP), is introduced, the existing results using ADP methods solve problems are reviewed. Then, this investigates various kinds identification analyzes feasibility combining meth...

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...

ADP-ribosyltransferases (ARTs) and ADP-ribosylhydrolases (ARHs) catalyze opposing reactions, which are termed ADP-ribosylation and de-ADP-ribosylation. ARTs transfer the ADP-ribose unit from NAD (nicotinamide adenine dinucleotide) onto an acceptor, while ARHs release the ADP-ribose from the target. Like protein phosphorylation, ADP-ribosylation is a posttranslational modification regulating pro...

[adenine-U-14C]ADP-ribose-agmatine and [adenineU-’4C]ADP-ribose-histone were synthesized by an NAD:arginine ADP-ribosyltransferase from [’*C]NAD and agmatine and histone, respectively. The pseudofirst order rate constants for breakdown of the two components either in 0.4 N NaOH or in 0.4 M neutral hydroxylamine were identical. Hydroxylamine treatment of [‘4C]ADP-ribose-agmatine or [32P]ADP-ribo...

Introduction: The role of adipose tissue as energy storage and endocrine organ is an area interest in the treatment several diseases. This study aimed to evaluate blood adiponectin (ADP), leptin, tumor necrosis factor type alpha (TNF-alpha) concentrations, their prognostic value patients with exacerbated chronic heart failure (CHF). Methods results: following were assessed 64 consecutive hospit...

Abstract Background Adenosine diphosphate (ADP) plays a pivotal role in platelet activation. The purinergic ADP-receptor P2Y12 has therefore been targeted the treatment of cardiovascular disease (CVD) to prevent atherothrombosis (1). Beyond expression on platelets, receptors have also described hematopoietic stem and progenitor cells (LSK) (2). After myocardial infarction (MI), accelerated LSK ...

ADP-ribosylation is a post-translational modification of proteins that comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. It is catalyzed by ADP-ribosyltransferases, a family of currently 22 human proteins that all possess an ADP-ribosyltransferase catalytic domain. ADP-ribosylation is a reversible modificatio...

Most of the carbon used for starch biosynthesis in cereal endosperms is derived from ADP-glucose (ADP-Glc) synthesized by extra-plastidial AGPase activity, and imported directly across the amyloplast envelope. The properties of the wheat endosperm amyloplast ADP-Glc transporter were analysed with respect to substrate kinetics and specificities using reconstituted amyloplast envelope proteins in...

The adenovirus death protein (ADP) is expressed at late times during a lytic infection of species C adenoviruses. ADP promotes the release of progeny virus by accelerating the lysis and death of the host cell. Since some human lymphocytes survive while maintaining a persistent infection with species C adenovirus, we compared ADP expression in these cells with ADP expression in lymphocytes that ...