نتایج جستجو برای: adipokine
تعداد نتایج: 2102 فیلتر نتایج به سال:
OBJECTIVES Peroxisome proliferator-activated receptor gamma is the master regulator of adipocyte differentiation and controls many adipocyte genes in response to anti-diabetic thiazolidinediones (TZDs) and lipid-lowering fibrates. We hypothesized that the combination of TZD+fibrate may be better than the sulfonylurea + statin approach regarding modifying the adipokine profile in diabetic patien...
BACKGROUND Blood adipokines are associated with breast cancer risk; however, blood-breast adipokine correlations and factors that explain variation in adipokines are unknown. METHODS Plasma (n = 155) and breast (n = 85) leptin and adiponectin were assessed by immunoassays in women with no history of cancer. Multivariable-adjusted regression models were used to determine breast adipokine assoc...
Peptides secreted by adipose tissue (adipokines) may enter blood via capillaries or lymph. The relative importance of these pathways for a given adipokine might influence its biological effects. Because this has not been studied in any species, we measured the concentrations of seven adipokines and eight nonsecreted proteins in afferent peripheral lymph and venous plasma from 12 healthy men. Da...
Determining the leptin level in patients with abdominal obesity without signs of insulin resistance is necessary for stratifying into groups normal (metabolically neutral obesity) and increased adipokine activity. Objective — To compare prevalence metabolic disorders cardiovascular remodeling young middle-aged men "metabolically healthy" neutral" obesity. Material methods observational sample s...
Abstract Context Data on the presence/quantification of neurotrophic adipokines retinol-binding protein-4 (RBP4), clusterin, and pigment epithelium-derived factor (PEDF) in human cerebrospinal fluid (CSF) are scarce migration these across blood-brain barrier (BBB) is uncertain. Objective This work aimed to quantify RBP4, PEDF, clusterin paired serum CSF samples patients undergoing neurological ...
Background and Aims: The adipokine fatty-acid binding protein 4 (FABP4) has been implicated in the pathogenesis of cardiometabolic disorders. Blocking action FABP4 through genetic or pharmacological means a preclinical setting analyzing effects genetically reduced expression humans is suggested to protect against obesity-related metabolic derangements atherosclerosis. As cardiovascular disease ...
Adipose tissue is central to metabolic homeostasis, signaling in part through the secretion of molecules termed adipokines. Circadian rhythms play an important role in adipose physiology, with plasma adipokine concentration and approximately 20 % of the murine adipose transcriptome undergoing 24 h variation. However, due to the heterogeneity of adipose tissue and rhythmical input from both neur...
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